Investigations on antimicrobial and antitubercular activity of some 4,5-dihydro-1h-pyrazole and chalcone derivatives
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
University of Ankara
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: In this study, first of all, chalcones and the compounds in the structure of 4,5-dihydro-1H-pyrazole, which are formed by ring closure as a result of the reaction of the chalcones with hydrazides were synthesized and the antimicrobial and antitubercular effects of all synthesized compounds were investigated. Material and Method: 4,5-Dihydro-1H-pyrazole derivatives were obtained as a result of the reaction of chalcones acquired by the reaction of benzaldehyde and acetophenone derivatives in methanol in alkaline medium, with hydrazide derivatives in methanol. The antimicrobial effects of these synthesized compounds were determined by microdilution method and their antitubercular effects were determined by microplate alamar blue assay. Result and Discussion: Compounds in the structure of 4,5-dihydro-1H-pyrazole were found to be more effective than chalcones against Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Pseudomonas aeruginosa isolate (gentamicin resistant) and Candida albicans. Against the strain of Staphylococcus aureus, chalcones were found to be more effective than 4,5-dihydro-1H-pyrazole derivatives. Both chalcones and 4,5-dihydro-1H-pyrazole derivatives showed similar effect against Staphylococcus aureus isolate (MRSA) and Mycobacterium tuberculosis. Compound B21 had the same activity with fluconazole against Candida krusei. Compound B20 was found to be more effective than fluconazole against Candida krusei. © 2021 University of Ankara. All rights reserved.
Açıklama
Anahtar Kelimeler
4; 5-Dihydro-1h-Pyrazole; Antimicrobial Activity; Antitubercular Activity; Chalcone, 4,5 Dihydro 1h Pyrazole; Acetophenone Derivative; Benzaldehyde; Chalcone Derivative; Fluconazole; Gentamicin; Hydrazide; Hydrazide Derivative; Methanol; Pyrazole Derivative; Unclassified Drug; Unclassified Drug; Antibiotic Resistance; Antimicrobial Activity; Article; Bacterial Strain; Bacterium Isolate; Broth Dilution; Candida Albicans; Drug Synthesis; Escherichia Coli; Methicillin Resistant Staphylococcus Aureus; Mycobacterium Tuberculosis; Nonhuman; Pichia Kudriavzevii; Pseudomonas Aeruginosa; Resazurin Assay; Staphylococcus Aureus
Kaynak
Ankara Universitesi Eczacilik Fakultesi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
45
Sayı
2
