Immunohistochemical demonstration of cytochrome oxidase in different parts of the central nervous system: A comparative experimental study

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dc.authoridAktas, Ranan/0000-0002-4474-7371
dc.authorwosidAktas, Ranan/F-2910-2016
dc.contributor.authorTaskinalp, O
dc.contributor.authorAktas, RG
dc.contributor.authorCigali, B
dc.contributor.authorKutlu, AK
dc.date.accessioned2024-06-12T11:19:47Z
dc.date.available2024-06-12T11:19:47Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCytochrome oxidase, the terminal enzyme of the electron transport chain, is a marker of the functional activity of the cell. In this study; localization of cytochrome oxidase in cerebrum, cerebellum, hippocampus, substantia nigra and choroid plexus of adult rats was investigated using immunohistochemical methods. Neural bodies were immunoreactive while neuroglial cells and axonal areas did not show significant immunostaining. The cerebral cortical substantia grisea region was stained almost homogeneously with cytochrome oxidase. In the cerebellar cortex, immunolabelling was more intense in the granular layer than the molecular layer. There was significant immunostaining in Purkinje cells. White matter, both in cerebrum and cerebellum, did not show immunoreactivity for cytochrome oxidase. Neurones in the hippocampus showed variable immunostaining; some of them were negative while others revealed high immunoreactivity. The neurones in substantia nigra were heavily labelled. Immunostaining for cytochrome oxidase in plexus choroideus epithelial cells was also remarkable. The morphological findings demonstrate the regions which most require and produce energy and reflect the differences in cellular activity in these parts of the central nervous system.en_US
dc.identifier.doi10.1046/j.1439-0264.2000.00281.x
dc.identifier.endpage349en_US
dc.identifier.issn0340-2096
dc.identifier.issue6en_US
dc.identifier.pmid11199478en_US
dc.identifier.scopus2-s2.0-0034516539en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.1046/j.1439-0264.2000.00281.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25339
dc.identifier.volume29en_US
dc.identifier.wosWOS:000166022100004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Wissenschafts-Verlag Gmbhen_US
dc.relation.ispartofAnatomia Histologia Embryologia-Journal Of Veterinary Medicine Series Cen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRat-Brainen_US
dc.subjectHistochemistryen_US
dc.subjectMitochondrialen_US
dc.subjectExpressionen_US
dc.subjectMetabolismen_US
dc.subjectSubunitsen_US
dc.subjectNeuronsen_US
dc.subjectHippocampusen_US
dc.subjectInvitroen_US
dc.subjectNuclearen_US
dc.titleImmunohistochemical demonstration of cytochrome oxidase in different parts of the central nervous system: A comparative experimental studyen_US
dc.typeArticleen_US

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