Effects of caffeic acid phenethyl ester on glycerol-induced acute renal failure in rats

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dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.contributor.authorAydogdu, N
dc.contributor.authorAtmaca, G
dc.contributor.authorYalcin, O
dc.contributor.authorBatcioglu, K
dc.contributor.authorKaymak, K
dc.date.accessioned2024-06-12T10:50:36Z
dc.date.available2024-06-12T10:50:36Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstract1. Free radicals and nitric oxide (NO) play a crucial role in the pathogenesis of myoglobinuric acute renal failure (ARE). The aim of the present study was to investigate the effects of caffeic acid phenethyl ester (CAPE), an anti-oxidant, on the myoglobinuric ARF induced by intramusculer hypertonic glycerol injection. 2. Thirty rats were divided equally into three groups. Rats in group I were given saline and those in groups 2 and 3 were injected with glycerol (10 mL/kg, i.m.). Concomitant and 24 It after glycerol injection, CAPE (10 mumol/kg, i.p.) was administered to group 3 rats. Forty-eight hours after glycerol injection, blood samples and kidney tissues of rats were taken under anaesthesia. 3. Plasma concentrations of urea, creatinine, malondialdehyde (MDA) and NO were determined, as were superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities and MDA levels in kidney tissues. Kidney morphology was also investigated. 4. In the group receiving CAPE, although SOD enzyme activity was found to be increased, we failed to find any protective effect of CAPE on other parameters investigated. Moreover, although CAPE significantly decreased NO levels, it increased plasma concentrations of urea and MDA. 5. We suggest that the effect of CAPE in decreasing NO concentrations may further increase the renal ischaemia in this model. Thus, CAPE may have a worsening rather than beneficial effect under these conditions in this model of ARF.en_US
dc.identifier.doi10.1111/j.1440-1681.2004.04050.x
dc.identifier.endpage579en_US
dc.identifier.issn0305-1870
dc.identifier.issn1440-1681
dc.identifier.issue9en_US
dc.identifier.pmid15479163en_US
dc.identifier.scopus2-s2.0-4944262741en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage575en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1681.2004.04050.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18067
dc.identifier.volume31en_US
dc.identifier.wosWOS:000224248600003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical And Experimental Pharmacology And Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Renal Failureen_US
dc.subjectAnti-Oxidant Enzymesen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectGlycerolen_US
dc.subjectLipid Peroxidationen_US
dc.subjectNitric Oxideen_US
dc.subjectNitric-Oxideen_US
dc.subjectReperfusion Injuryen_US
dc.subjectProtective Roleen_US
dc.subjectRhabdomyolysisen_US
dc.subjectInhibitoren_US
dc.subjectTissueen_US
dc.subjectCapeen_US
dc.subjectLungen_US
dc.titleEffects of caffeic acid phenethyl ester on glycerol-induced acute renal failure in ratsen_US
dc.typeArticleen_US

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