Effects of caffeic acid phenethyl ester on glycerol-induced acute renal failure in rats
Küçük Resim Yok
Tarih
2004
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
1. Free radicals and nitric oxide (NO) play a crucial role in the pathogenesis of myoglobinuric acute renal failure (ARE). The aim of the present study was to investigate the effects of caffeic acid phenethyl ester (CAPE), an anti-oxidant, on the myoglobinuric ARF induced by intramusculer hypertonic glycerol injection. 2. Thirty rats were divided equally into three groups. Rats in group I were given saline and those in groups 2 and 3 were injected with glycerol (10 mL/kg, i.m.). Concomitant and 24 It after glycerol injection, CAPE (10 mumol/kg, i.p.) was administered to group 3 rats. Forty-eight hours after glycerol injection, blood samples and kidney tissues of rats were taken under anaesthesia. 3. Plasma concentrations of urea, creatinine, malondialdehyde (MDA) and NO were determined, as were superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities and MDA levels in kidney tissues. Kidney morphology was also investigated. 4. In the group receiving CAPE, although SOD enzyme activity was found to be increased, we failed to find any protective effect of CAPE on other parameters investigated. Moreover, although CAPE significantly decreased NO levels, it increased plasma concentrations of urea and MDA. 5. We suggest that the effect of CAPE in decreasing NO concentrations may further increase the renal ischaemia in this model. Thus, CAPE may have a worsening rather than beneficial effect under these conditions in this model of ARF.
Açıklama
Anahtar Kelimeler
Acute Renal Failure, Anti-Oxidant Enzymes, Caffeic Acid Phenethyl Ester, Glycerol, Lipid Peroxidation, Nitric Oxide, Nitric-Oxide, Reperfusion Injury, Protective Role, Rhabdomyolysis, Inhibitor, Tissue, Cape, Lung
Kaynak
Clinical And Experimental Pharmacology And Physiology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
31
Sayı
9
