CYTOTOXIC AND ANTIOXIDANT ACTIVITIES OF ALCHEMILLA MOLLIS (BUSER) ROTHM. AND ITS CONTITUENTS; HYPEROSIDE AND ISOQUERCETIN

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dc.authorscopusid57479054900
dc.authorscopusid57192305916
dc.authorscopusid55953375100
dc.authorscopusid55928879200
dc.authorscopusid15020374700
dc.contributor.authorAslı K.O.Ç.
dc.contributor.authorKurtul E.
dc.contributor.authorKarabay A.Z.
dc.contributor.authorTekin M.
dc.contributor.authorBahadir Acikara Ö.
dc.date.accessioned2024-06-12T10:25:59Z
dc.date.available2024-06-12T10:25:59Z
dc.date.issued2022
dc.description.abstractObjective: Alchemilla mollis (Buser) Rothm. (Rosaceae) is widely distributed in Europe, North Anatolia, Caucasus, North Iran. A commercial drug, "Herba Alchemillae" is obtained from aerial parts of A. mollis, is used for its astringent, diuretic, antispazmodic properties as well as for treatment of excessive menstruation and wounds in Bulgarian and Turkish folk medicine. Previous studies have reported that hyperoside, isoquercetin, miquelianin, cis-and trans-tiliroside, sinocrassoside D2 and rhodiolgin were detected in A. mollis. Present study is aimed to evaluate in vitro antioxidant effects and cytotoxic activities of A.mollis methanolic extract and its constituents, hyperoside and isoquercetin, on K562 leukemia cell line. Material and Method: Spectrophotometric MTT assay and NO radical scavenging assay have been used to test the cytotoxic effects and antioxidant activities, respectively. Result and Discussion: Results showed that A.mollis methanolic extract reduced cell viability of K562 cells at concentrations higher than 0.02 mg/ml whereas the compounds did not exhibit any cytotoxicity at same concentration range. Additionally, significant inhibition on NO radical production was observed for all tested materials. © 2022 University of Ankara. All rights reserved.en_US
dc.identifier.doi10.33483/jfpau.991921
dc.identifier.endpage85en_US
dc.identifier.issn2564-6524
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85125862085en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage78en_US
dc.identifier.urihttps://doi.org/10.33483/jfpau.991921
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16613
dc.identifier.volume46en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversity of Ankaraen_US
dc.relation.ispartofAnkara Universitesi Eczacilik Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlchemilla Mollis; Antileukemic Activity; Antioxidant Activity; Hyperoside; Isoquercetinen_US
dc.subjectHyperin; Isoquercetin; Nitric Oxide; Alchemilla; Alchemilla Mollis; Antileukemic Activity; Antioxidant Activity; Article; Cell Structure; Cell Viability; Drug Cytotoxicity; Free Radical Scavenging Assay; K-562 Cell Line; Mtt Assay; Spectrophotometryen_US
dc.titleCYTOTOXIC AND ANTIOXIDANT ACTIVITIES OF ALCHEMILLA MOLLIS (BUSER) ROTHM. AND ITS CONTITUENTS; HYPEROSIDE AND ISOQUERCETINen_US
dc.title.alternativeALCHEMILLA MOLLIS (BUSER) ROTHM. İLE BİLEŞENLERİ HİPEROZİT VE İZOKERSETİNİN SİTOTOKSİK VE ANTİOKSİDAN AKTİVİTELERİen_US
dc.typeArticleen_US

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