Reversible ototoxic effect of azithromycin and clarithromycin on transiently evoked otoacoustic emissions in guinea pigs

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dc.authoridUZUN, CEM/0000-0003-3233-7049
dc.authorwosidUZUN, CEM/K-3307-2012
dc.contributor.authorUzun, C
dc.contributor.authorKoten, M
dc.contributor.authorAdali, MK
dc.contributor.authorYorulmaz, F
dc.contributor.authorYagiz, R
dc.contributor.authorKarasalihoglu, AR
dc.date.accessioned2024-06-12T10:54:07Z
dc.date.available2024-06-12T10:54:07Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe possible cochlear toxicity of systemically applied macrolides-erythromycin (ER), azithromycin (AZ) and clarithromycin(CL)-was investigated in guinea pigs by measuring transiently evoked otoacoustic emissions (TEOA-Es). A single dose of 125 mg/kg intravenous (i.v.) ER caused no change in TEOAEs in guinea pigs (p>0.05), whereas AZ (45 mg/kg orally) and CL (75 mg/kg i.v.) reversibly reduced the emission response (p<0.05). The reversible reduction of TEOAE responses due to AZ and CL, which is in accordance with the clinical picture of AZ and CL ototoxicity, could likely be attributable to the transient dysfunction of outer hair cells. The present study reveals that at least one ototoxic effect of AZ and CL is on the inner ear. The results may also encourage planning clinical researches on TEOAE monitoring in patients receiving high doses of AZ or CL.en_US
dc.identifier.endpage628en_US
dc.identifier.issn0022-2151
dc.identifier.issue8en_US
dc.identifier.pmid11535141en_US
dc.identifier.scopus2-s2.0-0034903888en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage622en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18934
dc.identifier.volume115en_US
dc.identifier.wosWOS:000170490700002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHeadley Brothers Ltden_US
dc.relation.ispartofJournal Of Laryngology And Otologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAzithromycinen_US
dc.subjectAntibioticsen_US
dc.subjectMacrolideen_US
dc.subjectAdverse Effectsen_US
dc.subjectCochleaen_US
dc.subjectAudiometryen_US
dc.subjectHuman-Immunodeficiency-Virusen_US
dc.subjectComplex Lung-Diseaseen_US
dc.subjectInduced Hearing-Lossen_US
dc.subjectErythromycinen_US
dc.subjectPharmacokineticsen_US
dc.subjectAntibioticsen_US
dc.subjectInfectionsen_US
dc.subjectAidsen_US
dc.titleReversible ototoxic effect of azithromycin and clarithromycin on transiently evoked otoacoustic emissions in guinea pigsen_US
dc.typeArticleen_US

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