Reversible ototoxic effect of azithromycin and clarithromycin on transiently evoked otoacoustic emissions in guinea pigs
Küçük Resim Yok
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Headley Brothers Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The possible cochlear toxicity of systemically applied macrolides-erythromycin (ER), azithromycin (AZ) and clarithromycin(CL)-was investigated in guinea pigs by measuring transiently evoked otoacoustic emissions (TEOA-Es). A single dose of 125 mg/kg intravenous (i.v.) ER caused no change in TEOAEs in guinea pigs (p>0.05), whereas AZ (45 mg/kg orally) and CL (75 mg/kg i.v.) reversibly reduced the emission response (p<0.05). The reversible reduction of TEOAE responses due to AZ and CL, which is in accordance with the clinical picture of AZ and CL ototoxicity, could likely be attributable to the transient dysfunction of outer hair cells. The present study reveals that at least one ototoxic effect of AZ and CL is on the inner ear. The results may also encourage planning clinical researches on TEOAE monitoring in patients receiving high doses of AZ or CL.
Açıklama
Anahtar Kelimeler
Azithromycin, Antibiotics, Macrolide, Adverse Effects, Cochlea, Audiometry, Human-Immunodeficiency-Virus, Complex Lung-Disease, Induced Hearing-Loss, Erythromycin, Pharmacokinetics, Antibiotics, Infections, Aids
Kaynak
Journal Of Laryngology And Otology
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
115
Sayı
8
