Effects of mannitol and dopamine on renal function in coronary artery bypass surgery
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Anaesthesiology and Intensive Care Society
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To compare the effects of dopamine and mannitol which are used to reduce the negative effects of long-term cardio-pulmonary bypass (CPB) on kidney function in according to manner of administration and by the time. Material and Methods: Group 1 (n = 25 patients): Mannitol (M) 1 g kg -1 was added to a priming solution of CPB. Group 2 (n = 25 patients): Dopamine infusion (D) (2 mg kg-1 min-1 IV) was used from induction of anesthesia until end of the operation. Group 3 (n = 25 patients): D (2 mg kg-1 min-1 IV) was used from induction of anesthesia until end of the operation and M 1 g kg-1 in the priming solution of CPB. Group 4 (n = 25 patients) (Control Group): Furosemide was performed in case of a decrease of urine. The values of serum urea, creatinine, albumin, urine microalbumin, urine creatinine, serum cystatin-C were compared to preop and postop periods. Results: Postop Cystatin C levels in Group I, II, III were observed a significant rise. The levels of Microalbumin / creatinine ratio in urine in all the groups at postop were seen advanced statistical significant (p <0.01). Conclusion: To determine kidney damage we have observed that microalbumin / creatinine ratio in urine compared to the Cystatin C level is to be a more sensitive parameter. We think that the use of D (2 ?g kg -1 min-1) combined with M (1 g kg-1) added during CPB is more effective in terms of preventing adverse effects of CPB on renal function.
Açıklama
Anahtar Kelimeler
Coronary Surgery; Cystatin-C; Dopamine; Mannitol; Microalbumin, Albumin; Creatinine; Cystatin C; Dopamine; Furosemide; Mannitol; Urea; Albumin Blood Level; Anesthesia Induction; Article; Comparative Study; Controlled Study; Coronary Artery Bypass Surgery; Creatinine Blood Level; Human; Kidney Function; Major Clinical Study; Urea Blood Level; Urine Level
Kaynak
Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
20
Sayı
1
