Effects of Vitamin A and E on arginase activity, ornithine and urea levels in brain tissues of rats on long-term alcohol administration

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dc.contributor.authorKundak, Ayse A.
dc.contributor.authorErbas, Hakan
dc.contributor.authorGuelen, Sendogan
dc.contributor.authorDoekmeci, Guelbin
dc.contributor.authorCelik, Hueseyin
dc.contributor.authorOezcan, Turgut
dc.date.accessioned2024-06-12T10:52:28Z
dc.date.available2024-06-12T10:52:28Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: The effect of long-term alcohol administration on brain arginase enzyme activity, ornithine and urea levels and the changes induced by administration of vitamins C and E were investigated. Study Design: I Seventy-five, male Wistar Albino rats between 4-6 months of age were used. Five study groups, each consisting of 15 rats were formed. The first group received oral glucose with a calorie value equivalent to alcohol. The second group received alcohol, the third, fourth and fifth groups received vitamins C, E and C+E, respectively, in addition to alcohol, for 20 weeks. All animals were sacrificed by the end of 20 weeks and arginase activity, ornithine and urea levels were measured in brain tissue samples. Results: In the treatment groups, arginase activities, ornithine and urea levels were significantly higher than the alcohol group (group 2). Conclusion: These results suggest that the nitric oxide synthase (NOS) enzyme which. isshown to. have increased in chronic alcohol intake, may cause a decrease in arginase enzyme activity via depleting the L-arginine pool. Antioxiclant replacement therapy may increase the arginase enzyme activity and therefore lead to a decrease in nitric oxide production which has been shown to have some negative effects. On the other hand, simultaneously increased polyamine production may potentiate the beneficial effects of these vitamins. Thus, vitamins C and E may prove to be effective in reducing the deleterious effects of chronic alcohol consumption.en_US
dc.identifier.endpage55en_US
dc.identifier.issn1301-3149
dc.identifier.issue1en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18717
dc.identifier.volume24en_US
dc.identifier.wosWOS:000257598600010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArginaseen_US
dc.subjectAscorbic Aciden_US
dc.subjectBrainen_US
dc.subjectOrnithineen_US
dc.subjectUreaen_US
dc.subjectVitamin Een_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectOxidative Stressen_US
dc.subjectArginine Metabolismen_US
dc.subjectEthanolen_US
dc.titleEffects of Vitamin A and E on arginase activity, ornithine and urea levels in brain tissues of rats on long-term alcohol administrationen_US
dc.typeArticleen_US

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