Effects of Vitamin A and E on arginase activity, ornithine and urea levels in brain tissues of rats on long-term alcohol administration
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves Yayincilik, Ibrahim Kara
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: The effect of long-term alcohol administration on brain arginase enzyme activity, ornithine and urea levels and the changes induced by administration of vitamins C and E were investigated. Study Design: I Seventy-five, male Wistar Albino rats between 4-6 months of age were used. Five study groups, each consisting of 15 rats were formed. The first group received oral glucose with a calorie value equivalent to alcohol. The second group received alcohol, the third, fourth and fifth groups received vitamins C, E and C+E, respectively, in addition to alcohol, for 20 weeks. All animals were sacrificed by the end of 20 weeks and arginase activity, ornithine and urea levels were measured in brain tissue samples. Results: In the treatment groups, arginase activities, ornithine and urea levels were significantly higher than the alcohol group (group 2). Conclusion: These results suggest that the nitric oxide synthase (NOS) enzyme which. isshown to. have increased in chronic alcohol intake, may cause a decrease in arginase enzyme activity via depleting the L-arginine pool. Antioxiclant replacement therapy may increase the arginase enzyme activity and therefore lead to a decrease in nitric oxide production which has been shown to have some negative effects. On the other hand, simultaneously increased polyamine production may potentiate the beneficial effects of these vitamins. Thus, vitamins C and E may prove to be effective in reducing the deleterious effects of chronic alcohol consumption.
Açıklama
Anahtar Kelimeler
Arginase, Ascorbic Acid, Brain, Ornithine, Urea, Vitamin E, Nitric-Oxide Synthase, Oxidative Stress, Arginine Metabolism, Ethanol
Kaynak
Trakya Universitesi Tip Fakultesi Dergisi
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
24
Sayı
1
