The effect of sildenafil on rats with adenine-Induced chronic kidney disease

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dc.authoridhttp://orcid.org/0000-0002-2500-7781en_US
dc.authoridhttp://orcid.org/0000-0002-8349-6202en_US
dc.contributor.authorAli, Badreldin H.
dc.contributor.authorAl Za'abi, Mohammed
dc.contributor.authorAdham, Sirin A.
dc.contributor.authorAl Suleimani, Yousuf
dc.contributor.authorKaraca, Turan
dc.contributor.authorManoj, Priyadarsini
dc.contributor.authorAl Kalbani, Jamila
dc.contributor.authorYasin, Javid
dc.contributor.authorNemmar, Abderrahim
dc.date.accessioned2019-06-26T06:59:19Z
dc.date.available2019-06-26T06:59:19Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Anabilim Dalıen_US
dc.descriptionKaraca, Turan (Trakya author)en_US
dc.description.abstractThe erectile dysfunction drug sildenafil has cardiopulmonary protective actions, and a nephroprotective action in cisplatin and ischemia-reperfusion- induced acute kidney injury. Here, we assessed its possible ameliorative action in a model of chronic kidney disease (CKD) using adenine feeding. Eight groups of rats were treated with saline (controls), adenine (0.25% w/w in feed daily for 5 weeks), and oral sildenafil (0.1, 0.5 or 2.5 mg/kg), either alone, or concomitantly with adenine. Urine was collected 24 h after the end of the treatments from all rats and blood pressure measured, followed by collection of blood and kidneys for the measurement of several functional, biochemical and histopathological parameters. Adenine treatment reduced body weight, creatinine renal clearance, and increased water intake and urine output, as well as the plasma concentrations of urea and creatinine, neutrophil gelatinase-associated lipocalin, and N-acetyl-beta-D-glucosaminidase activity, and albumin in urine. Adenine also increased the concentrations of the uremic toxins indoxyl sulfate, uric acid and phosphate, and a number of proteins and inflammatory cytokines, and decreased that of several anti - oxidant indices. Renal histopathological markers of damage (inflammation and fibrosis) were significantly increased by adenine. Sildenafil, given simultaneously with adenine, induced a dose - dependent improvements in most of the above parameters, suggesting its possible use as adjunct treatment for CKD in humans.en_US
dc.identifier.citationAli, B. H., Al Za'abi, M., Adham, S. A., Al Suleimani, Y., Karaca, T., Manoj, P., ... & Nemmar, A. (2018). The effect of sildenafil on rats with adenine—Induced chronic kidney disease. Biomedicine & Pharmacotherapy, 108, 391-402.en_US
dc.identifier.doi10.1016/j.biopha.2018.09.061en_US
dc.identifier.endpage402en_US
dc.identifier.pmid30236848en_US
dc.identifier.scopus2-s2.0-85053429513en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage391en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2018.09.061
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4232
dc.identifier.volume108en_US
dc.identifier.wosWOS:000450101800046en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Franceen_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectAdenineen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectNephroprotectionen_US
dc.subjectRatsen_US
dc.subjectSildenafilen_US
dc.subjectChronic-Renal-Failureen_US
dc.subjectWhite Adipose-Tissueen_US
dc.subjectIndoxyl Sulfateen_US
dc.subjectModelen_US
dc.subjectInjuryen_US
dc.subjectNephrotoxicityen_US
dc.subjectCyclosporineen_US
dc.subjectInflammationen_US
dc.subjectProgressionen_US
dc.subjectInhibitionen_US
dc.titleThe effect of sildenafil on rats with adenine-Induced chronic kidney diseaseen_US
dc.typeArticleen_US

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