The effect of sildenafil on rats with adenine-Induced chronic kidney disease
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier France
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The erectile dysfunction drug sildenafil has cardiopulmonary protective actions, and a nephroprotective action in cisplatin and ischemia-reperfusion- induced acute kidney injury. Here, we assessed its possible ameliorative action in a model of chronic kidney disease (CKD) using adenine feeding. Eight groups of rats were treated with saline (controls), adenine (0.25% w/w in feed daily for 5 weeks), and oral sildenafil (0.1, 0.5 or 2.5 mg/kg), either alone, or concomitantly with adenine. Urine was collected 24 h after the end of the treatments from all rats and blood pressure measured, followed by collection of blood and kidneys for the measurement of several functional, biochemical and histopathological parameters. Adenine treatment reduced body weight, creatinine renal clearance, and increased water intake and urine output, as well as the plasma concentrations of urea and creatinine, neutrophil gelatinase-associated lipocalin, and N-acetyl-beta-D-glucosaminidase activity, and albumin in urine. Adenine also increased the concentrations of the uremic toxins indoxyl sulfate, uric acid and phosphate, and a number of proteins and inflammatory cytokines, and decreased that of several anti - oxidant indices. Renal histopathological markers of damage (inflammation and fibrosis) were significantly increased by adenine. Sildenafil, given simultaneously with adenine, induced a dose - dependent improvements in most of the above parameters, suggesting its possible use as adjunct treatment for CKD in humans.
Açıklama
Karaca, Turan (Trakya author)
Anahtar Kelimeler
Adenine, Chronic Kidney Disease, Nephroprotection, Rats, Sildenafil, Chronic-Renal-Failure, White Adipose-Tissue, Indoxyl Sulfate, Model, Injury, Nephrotoxicity, Cyclosporine, Inflammation, Progression, Inhibition
Kaynak
Biomedicine & Pharmacotherapy
WoS Q Değeri
Q1
Scopus Q Değeri
N/A
Cilt
108
Sayı
Künye
Ali, B. H., Al Za'abi, M., Adham, S. A., Al Suleimani, Y., Karaca, T., Manoj, P., ... & Nemmar, A. (2018). The effect of sildenafil on rats with adenine—Induced chronic kidney disease. Biomedicine & Pharmacotherapy, 108, 391-402.
