Investigation of the risk factors for extended spectrum beta-lactamase production in patients with upper urinary tract infections

Basit Öğe Kaydı
dc.authorscopusid55865109300
dc.authorscopusid27169492000
dc.authorscopusid6701537113
dc.contributor.authorDurmuş G.
dc.contributor.authorKulo?lu F.
dc.contributor.authorAkata F.
dc.date.accessioned2024-06-12T10:26:33Z
dc.date.available2024-06-12T10:26:33Z
dc.date.issued2014
dc.description.abstractObjective: In this study, we aimed to determine the frequency of extended spectrum beta-lactamase (ESBL) production in gram negative bacteria isolated from patients with upper urinary tract infection (UTI) and the risk factors causing ESBL production in these patients. Material and Methods: The medical records of the adult patients with upper UTI episodes admitted to Infectious Diseases Unit of Trakya University Hospital between May 1, 2007 and July 30, 2008 were reviewed retrospectively. We planned a case-control study. Eighty four patients with urine cultures positive for Escherichia coli and Klebsiella pneumoniae were included in the study. Study patients were those with ESBL producing E. coli and K. pneumoniae positive urine cultures (n=32), and the control patients were those with non-ESBL producing E. coli and K. pneumoniae positive urine cultures (n=52). The study group was compared with the control group for age, sex, underlying systemic disease, malignity, immunosupressive therapy, urinary catheterization, previous use of antibiotics, previous surgeries, hospitalization, nosocomial infection and antibiotic susceptibility. Results: Factors significantly associated with ESBL positive upper UTI episodes on univariate analysis were nosocomial infection (p<0.001), malignity (p=0.009), neurologic dysfunction (p=0.003), previous use of antibiotics (p<0.001), hospitalization in the previous six months (p<0.001), previous surgery (p=0.001), indwelling urinary catheterization (p=0.011) and recurrent urinary tract infection (p=0.002). We detected a markedly decrease in susceptibility of ESBL- positive strains for different groups of antibiotics. Conclusion: If patient risk factors associated with ESBL production, local ESBL production and antibiotic susceptibilities are known, the success of the treatment modalities directed to these patients may improve. © 2014 by Türkiye Klinikleri.en_US
dc.identifier.doi10.5336/medsci.2012-31997
dc.identifier.endpage8en_US
dc.identifier.issn1300-0292
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84901609285en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.5336/medsci.2012-31997
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16881
dc.identifier.volume34en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeta-Lactamases; Escherichia Coli; Klebsiella Pneumoniae; Risk Factor; Urinary Tract Infectionsen_US
dc.subjectExtended Spectrum Beta Lactamase; Antibiotic Sensitivity; Article; Bladder Catheterization; Case Control Study; Controlled Study; Escherichia Coli Infection; Gram Negative Bacterium; Hospital Infection; Hospitalization; Human; Immunosuppressive Treatment; Klebsiella Pneumoniae Infection; Major Clinical Study; Retrospective Study; Risk Assessment; Systemic Disease; Urinary Tract Infectionen_US
dc.titleInvestigation of the risk factors for extended spectrum beta-lactamase production in patients with upper urinary tract infectionsen_US
dc.title.alternativeÜst üriner sistem enfeksiyonu tani{dotless}si{dotless}yla İzlenen hastalarda genişlemiş spektrumlu beta-laktamaz üretimine neden olan risk faktörlerinin araşti{dotless}ri{dotless}lmasi{dotless}en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu