Investigation of the risk factors for extended spectrum beta-lactamase production in patients with upper urinary tract infections
Küçük Resim Yok
Tarih
2014
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Klinikleri
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: In this study, we aimed to determine the frequency of extended spectrum beta-lactamase (ESBL) production in gram negative bacteria isolated from patients with upper urinary tract infection (UTI) and the risk factors causing ESBL production in these patients. Material and Methods: The medical records of the adult patients with upper UTI episodes admitted to Infectious Diseases Unit of Trakya University Hospital between May 1, 2007 and July 30, 2008 were reviewed retrospectively. We planned a case-control study. Eighty four patients with urine cultures positive for Escherichia coli and Klebsiella pneumoniae were included in the study. Study patients were those with ESBL producing E. coli and K. pneumoniae positive urine cultures (n=32), and the control patients were those with non-ESBL producing E. coli and K. pneumoniae positive urine cultures (n=52). The study group was compared with the control group for age, sex, underlying systemic disease, malignity, immunosupressive therapy, urinary catheterization, previous use of antibiotics, previous surgeries, hospitalization, nosocomial infection and antibiotic susceptibility. Results: Factors significantly associated with ESBL positive upper UTI episodes on univariate analysis were nosocomial infection (p<0.001), malignity (p=0.009), neurologic dysfunction (p=0.003), previous use of antibiotics (p<0.001), hospitalization in the previous six months (p<0.001), previous surgery (p=0.001), indwelling urinary catheterization (p=0.011) and recurrent urinary tract infection (p=0.002). We detected a markedly decrease in susceptibility of ESBL- positive strains for different groups of antibiotics. Conclusion: If patient risk factors associated with ESBL production, local ESBL production and antibiotic susceptibilities are known, the success of the treatment modalities directed to these patients may improve. © 2014 by Türkiye Klinikleri.
Açıklama
Anahtar Kelimeler
Beta-Lactamases; Escherichia Coli; Klebsiella Pneumoniae; Risk Factor; Urinary Tract Infections, Extended Spectrum Beta Lactamase; Antibiotic Sensitivity; Article; Bladder Catheterization; Case Control Study; Controlled Study; Escherichia Coli Infection; Gram Negative Bacterium; Hospital Infection; Hospitalization; Human; Immunosuppressive Treatment; Klebsiella Pneumoniae Infection; Major Clinical Study; Retrospective Study; Risk Assessment; Systemic Disease; Urinary Tract Infection
Kaynak
Turkiye Klinikleri Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
34
Sayı
1
