Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives

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dc.authoridULGER, Mahmut/0000-0001-6649-4195;
dc.authorwosidULGER, Mahmut/AAH-4521-2019
dc.authorwosidDündar, Yasemin/AHB-0505-2022
dc.authorwosidONURDAG, Fatma KAYNAK/T-2518-2017
dc.contributor.authorAkcay, Sevilay
dc.contributor.authorUlger, Mahmut
dc.contributor.authorOnurdag, Fatma Kaynak
dc.contributor.authorDundar, Yasemin
dc.date.accessioned2024-06-12T11:13:10Z
dc.date.available2024-06-12T11:13:10Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study, new pyrido [3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl) pyrido [3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido [3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.en_US
dc.identifier.doi10.17344/acsi.2018.4590
dc.identifier.endpage938en_US
dc.identifier.issn1318-0207
dc.identifier.issn1580-3155
dc.identifier.issue4en_US
dc.identifier.pmid33562929en_US
dc.identifier.scopus2-s2.0-85061306584en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage932en_US
dc.identifier.urihttps://doi.org/10.17344/acsi.2018.4590
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23456
dc.identifier.volume65en_US
dc.identifier.wosWOS:000453240200017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSlovensko Kemijsko Drustvoen_US
dc.relation.ispartofActa Chimica Slovenicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPyrido [3,4-D]Pyridazine Derivativesen_US
dc.subjectPyrido [3,4-D]Pyridazin-4(3H)-Oneen_US
dc.subjectPyrido [3,4-D]Pyridazin-1(2H)-Oneen_US
dc.subjectAntimycobacterial Activityen_US
dc.subjectPyrazinamideen_US
dc.titleStudy on Synthesis and Biological Activity of Some Pyridopyridazine Derivativesen_US
dc.typeArticleen_US

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