Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives
Küçük Resim Yok
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Slovensko Kemijsko Drustvo
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, new pyrido [3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl) pyrido [3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido [3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.
Açıklama
Anahtar Kelimeler
Pyrido [3,4-D]Pyridazine Derivatives, Pyrido [3,4-D]Pyridazin-4(3H)-One, Pyrido [3,4-D]Pyridazin-1(2H)-One, Antimycobacterial Activity, Pyrazinamide
Kaynak
Acta Chimica Slovenica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
65
Sayı
4
