Potent tyrosinase inhibitors from Trifolium balansae

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dc.authoridSABUDAK, Temine/0000-0003-4384-4265
dc.authoridChoudhary, M. Iqbal/0000-0001-5356-3585
dc.authorwosidchaudhary, Muhammad iqbal/E-8638-2015
dc.authorwosidSABUDAK, Temine/AAG-6784-2019
dc.authorwosidChoudhary, M. Iqbal/C-8633-2012
dc.contributor.authorSabudak, Temine
dc.contributor.authorKhan, Mahmut Tareq Hassan
dc.contributor.authorChoudhary, M. Iqbal
dc.contributor.authorOksuz, Sevil
dc.date.accessioned2024-06-12T11:16:42Z
dc.date.available2024-06-12T11:16:42Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTrifolium balansae ( Leguminosae) yielded a phytylester, phytyl-1-hexanoate, three steroids, stigmast-5-ene-3 beta,26-diol, stigmast-5-ene-3-ol and campesterol, and an alcohol, pentacosanol which were reported for the first time from T. balansae. The structures of the isolates were determined by 1D and 2DNMR techniques and MS spectroscopy. Compounds 1 - 5 were tested for their enzyme tyrosinase activity. While compounds 1 and 5 did not show any inhibition against the enzyme tyrosinase, compounds 2, 3, and 4 exhibited potent inhibition against tyrosinase. Highly potent ( IC50 = 2.39 mu M) inhibition was found by compound 2, when compared with the standard tyrosinase inhibitors Kojic acid and L-mimosine.en_US
dc.identifier.doi10.1080/14786410500196821
dc.identifier.endpage670en_US
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.issue7en_US
dc.identifier.pmid16901809en_US
dc.identifier.scopus2-s2.0-33745070297en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage665en_US
dc.identifier.urihttps://doi.org/10.1080/14786410500196821
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24408
dc.identifier.volume20en_US
dc.identifier.wosWOS:000238070000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrifolium Balansaeen_US
dc.subjectLeguminosaeen_US
dc.subjectSteroidsen_US
dc.subjectPhytylesteren_US
dc.subjectTyrosinase Inhibitionen_US
dc.subjectVitiligoen_US
dc.subjectHyperpigmentationen_US
dc.subjectChlorophyll-Aen_US
dc.subjectSide-Chainen_US
dc.subjectC-24en_US
dc.subjectC-13en_US
dc.titlePotent tyrosinase inhibitors from Trifolium balansaeen_US
dc.typeArticleen_US

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