Potent tyrosinase inhibitors from Trifolium balansae
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Trifolium balansae ( Leguminosae) yielded a phytylester, phytyl-1-hexanoate, three steroids, stigmast-5-ene-3 beta,26-diol, stigmast-5-ene-3-ol and campesterol, and an alcohol, pentacosanol which were reported for the first time from T. balansae. The structures of the isolates were determined by 1D and 2DNMR techniques and MS spectroscopy. Compounds 1 - 5 were tested for their enzyme tyrosinase activity. While compounds 1 and 5 did not show any inhibition against the enzyme tyrosinase, compounds 2, 3, and 4 exhibited potent inhibition against tyrosinase. Highly potent ( IC50 = 2.39 mu M) inhibition was found by compound 2, when compared with the standard tyrosinase inhibitors Kojic acid and L-mimosine.
Açıklama
Anahtar Kelimeler
Trifolium Balansae, Leguminosae, Steroids, Phytylester, Tyrosinase Inhibition, Vitiligo, Hyperpigmentation, Chlorophyll-A, Side-Chain, C-24, C-13
Kaynak
Natural Product Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
20
Sayı
7
