GENOTOXIC AND CYTOTOXIC EFFECTS OF A PYRETHROID INSECTICIDE LAMBDA-CYHALOTHRIN ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES INVESTIGATED BY CHROMOSOME ABERRATION AND FLOW CYTOMETRY ASSAYS

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dc.authoridGokalp, Fulya Dilek/0000-0001-8219-6657
dc.contributor.authorMuranli, Fulya Dilek Gokalp
dc.date.accessioned2024-06-12T11:02:02Z
dc.date.available2024-06-12T11:02:02Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractGenotoxic and cytotoxic effect of different concentrations of Lambda-cyhalothrin (LCT) (3.75, 7.5, 15 and 30 mu M/ml) were investigated in human peripheral blood lymphocyte culture by chromosome aberration (CA) and flow cytometry (FC) assays. Human peripheral whole blood cultures were treated with four concentrations of LCT which were prepared by using distilled water and Dimethyl Sulfoxide (DMSO) for 48 hours. Although LCT did not significantly induce CA frequency in human peripheral blood, the insecticide showed a genotoxic effect due to decrease of Mitotic Index (MI) and G2 phase ratios and high concentrations of LCT demonstrated an accumulation of aneuploid population in early S phase that might mean its damaging effect on DNA molecule.en_US
dc.identifier.endpage1763en_US
dc.identifier.issn1018-4619
dc.identifier.issue9Aen_US
dc.identifier.startpage1758en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21119
dc.identifier.volume18en_US
dc.identifier.wosWOS:000270702400012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlow Cytometryen_US
dc.subjectChromosome Aberrationsen_US
dc.subjectHuman Peripheral Blood Cultureen_US
dc.subjectLambda-Cyhalothrinen_US
dc.subjectRat Bone-Marrowen_US
dc.subjectEpithelial-Cellsen_US
dc.subjectAcute Toxicityen_US
dc.subjectIn-Vitroen_US
dc.subjectCypermethrinen_US
dc.subjectPesticidesen_US
dc.subjectPermethrinen_US
dc.subjectInductionen_US
dc.subjectDursbanen_US
dc.subjectDamageen_US
dc.titleGENOTOXIC AND CYTOTOXIC EFFECTS OF A PYRETHROID INSECTICIDE LAMBDA-CYHALOTHRIN ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES INVESTIGATED BY CHROMOSOME ABERRATION AND FLOW CYTOMETRY ASSAYSen_US
dc.typeArticleen_US

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