GENOTOXIC AND CYTOTOXIC EFFECTS OF A PYRETHROID INSECTICIDE LAMBDA-CYHALOTHRIN ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES INVESTIGATED BY CHROMOSOME ABERRATION AND FLOW CYTOMETRY ASSAYS
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Parlar Scientific Publications (P S P)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Genotoxic and cytotoxic effect of different concentrations of Lambda-cyhalothrin (LCT) (3.75, 7.5, 15 and 30 mu M/ml) were investigated in human peripheral blood lymphocyte culture by chromosome aberration (CA) and flow cytometry (FC) assays. Human peripheral whole blood cultures were treated with four concentrations of LCT which were prepared by using distilled water and Dimethyl Sulfoxide (DMSO) for 48 hours. Although LCT did not significantly induce CA frequency in human peripheral blood, the insecticide showed a genotoxic effect due to decrease of Mitotic Index (MI) and G2 phase ratios and high concentrations of LCT demonstrated an accumulation of aneuploid population in early S phase that might mean its damaging effect on DNA molecule.
Açıklama
Anahtar Kelimeler
Flow Cytometry, Chromosome Aberrations, Human Peripheral Blood Culture, Lambda-Cyhalothrin, Rat Bone-Marrow, Epithelial-Cells, Acute Toxicity, In-Vitro, Cypermethrin, Pesticides, Permethrin, Induction, Dursban, Damage
Kaynak
Fresenius Environmental Bulletin
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
18
Sayı
9A
