The effects of melatonin on postoperative intraabdominal adhesion formation

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dc.contributor.authorHatipoglu, Ahmet
dc.contributor.authorTurkyilmaz, Zeliha
dc.contributor.authorMert, Selva
dc.date.accessioned2024-06-12T11:07:13Z
dc.date.available2024-06-12T11:07:13Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: Postoperative intraabdominal adhesion formation is a major clinical problem. No previous study was found, reporting the relationship between adhesion formation and melatonin administration, but melatonin, a strong antioxidant, is recognized to have certain effects on the progression of adhesion formation mechanism. It was therefore decided to investigate the effects of melatonin on postoperative adhesion formation. Materials and Methods: A total number of 24 Spraque-Dawley rats were utilized. Three groups, described as: Group A, sham laparatomy (n = 8), Group B, rats that underwent only ischemia-reperfusion (n = 8) and Group C, rats that underwent ischemia-reperfusion and were given 10 mg/kg melatonin solution i.v. (n = 8). For Groups B and C, the ileocolic vessels were clamped. Blood glutathione peroxidase levels of all study groups were assessed, then microscopic and macroscopic adhesion scores were evaluated. Results: Glutathione peroxidase levels of the melatonin-treated group were significantly higher and fibroblast proliferation and macroscopic adhesion scores were significantly lower, than in the melatonin-free group. Conclusion: The results of this study supported the hypothesis, that melatonin administration may prevent intraabdominal adhesions resulting from surgery.en_US
dc.identifier.doi10.3349/ymj.2007.48.4.659
dc.identifier.endpage664en_US
dc.identifier.issn0513-5796
dc.identifier.issue4en_US
dc.identifier.pmid17722239en_US
dc.identifier.scopus2-s2.0-34848918900en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage659en_US
dc.identifier.urihttps://doi.org/10.3349/ymj.2007.48.4.659
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21960
dc.identifier.volume48en_US
dc.identifier.wosWOS:000249306300013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherYonsei Univ College Medicineen_US
dc.relation.ispartofYonsei Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntraabdominal Adhesionen_US
dc.subjectMelatoninen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectPreventionen_US
dc.subjectProtectionen_US
dc.subjectMechanismsen_US
dc.subjectDamageen_US
dc.subjectRatsen_US
dc.titleThe effects of melatonin on postoperative intraabdominal adhesion formationen_US
dc.typeArticleen_US

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