The effects of melatonin on postoperative intraabdominal adhesion formation
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Yonsei Univ College Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: Postoperative intraabdominal adhesion formation is a major clinical problem. No previous study was found, reporting the relationship between adhesion formation and melatonin administration, but melatonin, a strong antioxidant, is recognized to have certain effects on the progression of adhesion formation mechanism. It was therefore decided to investigate the effects of melatonin on postoperative adhesion formation. Materials and Methods: A total number of 24 Spraque-Dawley rats were utilized. Three groups, described as: Group A, sham laparatomy (n = 8), Group B, rats that underwent only ischemia-reperfusion (n = 8) and Group C, rats that underwent ischemia-reperfusion and were given 10 mg/kg melatonin solution i.v. (n = 8). For Groups B and C, the ileocolic vessels were clamped. Blood glutathione peroxidase levels of all study groups were assessed, then microscopic and macroscopic adhesion scores were evaluated. Results: Glutathione peroxidase levels of the melatonin-treated group were significantly higher and fibroblast proliferation and macroscopic adhesion scores were significantly lower, than in the melatonin-free group. Conclusion: The results of this study supported the hypothesis, that melatonin administration may prevent intraabdominal adhesions resulting from surgery.
Açıklama
Anahtar Kelimeler
Intraabdominal Adhesion, Melatonin, Ischemia-Reperfusion Injury, Ischemia-Reperfusion, Prevention, Protection, Mechanisms, Damage, Rats
Kaynak
Yonsei Medical Journal
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
48
Sayı
4
