Main Genome Editing Tools: An Overview of the Literature, Future Applications and Ethical Questions

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dc.contributor.authorŞenödeyici, Eylül
dc.contributor.authorŞahintürk, Dengiz Koray
dc.contributor.authorAkbolat, Bilge Rana
dc.contributor.authorDindar, Arzu
dc.contributor.authorSefer, Selin
dc.contributor.authorAnğay, Gül Feride
dc.contributor.authorDemir, Selma
dc.date.accessioned2021-11-20T10:26:58Z
dc.date.available2021-11-20T10:26:58Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Anabilim Dalıen_US
dc.description.abstractThe popularity of genome editing technologies in the scientific community has been on the rise for several years. These technologies are slowly becoming a ray of hope for many patients with genetic diseases, thanks to their immense potential for clinical application. New genome editing tools are being rap- idly developed and introduced, while pre-existing ones are being perfected. In the process beginning with the completion of the Human Genome Project to the first clinical trials focusing on cancer immunotherapy and treating blindness, studies on genome editing have increased exponentially. The clustered regularly interspaced short palindromic repeats system is a Nobel Prize-winning genome editing tool celebrated by many researchers and is often praised due to its ease of use, low cost, and efficiency compared to other acknowledged genome editing tools. This review aims to discuss the historical development, working mechanisms, present and future clinical applications of zinc-finger nucleases, transcription activator-like effector nucleases, clustered regularly inter- spaced short palindromic repeats, and prime editors, while presenting the ethical aspects of using these genome editing tools. Keywords: Zinc-finger nucleases, transcription activator-like effector nucleases, clustered regularly interspaced short palindromic repeats, gene editingen_US
dc.identifier.dergipark962870en_US
dc.identifier.endpage57en_US
dc.identifier.issn2148-4724
dc.identifier.issn2548-0030
dc.identifier.issue2en_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://dergipark.org.tr/tr/pub/tmsj/issue/63592/962870
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/1861373
dc.identifier.urihttps://hdl.handle.net/20.500.14551/6236
dc.identifier.volume8en_US
dc.language.isoenen_US
dc.publisherTrakya Üniversitesien_US
dc.relation.ispartofTurkish Medical Student Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectZinc-finger nucleasesen_US
dc.subjecttranscription activator-like effector nucleasesen_US
dc.subjectclustered regularly interspaced short palindromic repeatsen_US
dc.subjectgene editingen_US
dc.titleMain Genome Editing Tools: An Overview of the Literature, Future Applications and Ethical Questionsen_US
dc.typeArticleen_US

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