Modulatory role of asymmetric dimethylarginine (ADMA) in cannabinoid tolerance and dependence

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T11:17:48Z
dc.date.available2024-06-12T11:17:48Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNumerous studies have shown that opioids and cannabinoids share some pharmacological properties. Accordingly, similarly to opioids, tolerance and dependence develops after chronic use of cannabinoids. Nitric oxide (NO) has been shown to play important roles both in opioid- and cannabinoid-induced tolerance and dependence. The endogenous nitric oxide synthase (NOS) inhibitor, ADMA, levels have been shown to elevate, and L-arginine/ADMA ratio has been shown to reduce in many cardiovascular/metabolic disorders. Recently, ADMA has also been proposed as a modulator of nociception in opiate tolerance and dependence. Taken together, we hypothesized that ADMA and/or L-arginine/ADMA ratio may play a modulatory role in tolerance and dependence to cannabinoids. (C) 2009 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.mehy.2009.02.013
dc.identifier.endpage214en_US
dc.identifier.issn0306-9877
dc.identifier.issue2en_US
dc.identifier.pmid19329260en_US
dc.identifier.scopus2-s2.0-67349195381en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2009.02.013
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24849
dc.identifier.volume73en_US
dc.identifier.wosWOS:000267354200028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCentral-Nervous-Systemen_US
dc.subjectNitric-Oxideen_US
dc.subjectOpioid Toleranceen_US
dc.subjectMorphine-Toleranceen_US
dc.subjectPhysical-Dependenceen_US
dc.subjectAbstinence Syndromeen_US
dc.subjectMiceen_US
dc.subjectCyclosporineen_US
dc.subjectPerspectivesen_US
dc.subjectAnalgesicsen_US
dc.titleModulatory role of asymmetric dimethylarginine (ADMA) in cannabinoid tolerance and dependenceen_US
dc.typeArticleen_US

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