Modulatory role of asymmetric dimethylarginine (ADMA) in cannabinoid tolerance and dependence
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Churchill Livingstone
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Numerous studies have shown that opioids and cannabinoids share some pharmacological properties. Accordingly, similarly to opioids, tolerance and dependence develops after chronic use of cannabinoids. Nitric oxide (NO) has been shown to play important roles both in opioid- and cannabinoid-induced tolerance and dependence. The endogenous nitric oxide synthase (NOS) inhibitor, ADMA, levels have been shown to elevate, and L-arginine/ADMA ratio has been shown to reduce in many cardiovascular/metabolic disorders. Recently, ADMA has also been proposed as a modulator of nociception in opiate tolerance and dependence. Taken together, we hypothesized that ADMA and/or L-arginine/ADMA ratio may play a modulatory role in tolerance and dependence to cannabinoids. (C) 2009 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Central-Nervous-System, Nitric-Oxide, Opioid Tolerance, Morphine-Tolerance, Physical-Dependence, Abstinence Syndrome, Mice, Cyclosporine, Perspectives, Analgesics
Kaynak
Medical Hypotheses
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
73
Sayı
2
