Congenital and Perinatal Cytomegalovirus Infections in the Neonatal Period: Case Series

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dc.contributor.authorCiftdemir, Nukhet Aladag
dc.contributor.authorAcunas, Betul
dc.date.accessioned2024-06-12T10:59:08Z
dc.date.available2024-06-12T10:59:08Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Cytomegalovirus infection when diagnosed in the first three weeks of life is generally accepted to be indicative of a congenital or vertical infection, whereas when cytomegalovirus infection is diagnosed after the first three weeks of life, it is generally considered as perinatal or horizontal infection. Since diagnosis of either a congenital or perinatal cytomegalovirus infection is challenging, as well as their treatment, this study aimed to address the issues about the diagnosis and treatment of congenital/perinatal cytomegalovirus infection by presenting a series of infants followed-up in our neonatal intensive care unit. Material and Methods: Medical records of newborn infants with congenital/perinatal cytomegalovirus infection who were admitted to our level ill neonatal intensive care unit between August 2015 and May 2018 were evaluated retrospectively. Only infants who received cytomegalovirus-specific therapy were included. Results: Out of 1039 infants admitted to the neonatal intensive care unit during the study period, 8 (0.8%) were diagnosed and treated for congenital/perinatal cytomegalovirus infections. All of them were preterm infants. Four infants found to be CMV positive during the first 21 days of life were diagnosed as congenital cytomegalovirus infection, while a perinatal and congenital infection differentiation could not be made in the rest of the patients. Anemia (75%), thrombocytopenia (62.5%) and hearing loss (62.5%) were the most common findings in patients with congenital/perinatal infection. None of the infants had chorioretinitis. Two infants (25%) with microcephaly had intracranial calcifications. Sepsis-like findings were present in three very preterm infants (37.5%). Cytomegalovirus-IgM was positive in all 8 infants with infection; however, serum CMV-DNA was positive in seven of them. All infants with moderate to severe symptoms were treated with ganciclovir and/or valganciclovir. Viral load decreased dramatically at the end of the treatment period. Conclusion: Cytomegalovirus infection, either congenital or perinatal, is a greater risk especially for preterm infants who may warrant and benefit from newborn cytomegalovirus screening, early detection, and effective antiviral treatment.en_US
dc.identifier.doi10.5578/ced.202010
dc.identifier.endpage26en_US
dc.identifier.issn1307-1068
dc.identifier.issn1308-5271
dc.identifier.issue1en_US
dc.identifier.startpage21en_US
dc.identifier.trdizinid364580en_US
dc.identifier.urihttps://doi.org/10.5578/ced.202010
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/364580
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20326
dc.identifier.volume14en_US
dc.identifier.wosWOS:000534498100005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofJournal Of Pediatric Infectionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytomegalovirusen_US
dc.subjectCongenital Infectionen_US
dc.subjectPerinatal Infectionen_US
dc.subjectPretermen_US
dc.subjectNewbornen_US
dc.subjectPreterm Infantsen_US
dc.subjectTransmissionen_US
dc.subjectTherapyen_US
dc.subjectDiseaseen_US
dc.titleCongenital and Perinatal Cytomegalovirus Infections in the Neonatal Period: Case Seriesen_US
dc.typeArticleen_US

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