Congenital and Perinatal Cytomegalovirus Infections in the Neonatal Period: Case Series
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves Yayincilik, Ibrahim Kara
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Cytomegalovirus infection when diagnosed in the first three weeks of life is generally accepted to be indicative of a congenital or vertical infection, whereas when cytomegalovirus infection is diagnosed after the first three weeks of life, it is generally considered as perinatal or horizontal infection. Since diagnosis of either a congenital or perinatal cytomegalovirus infection is challenging, as well as their treatment, this study aimed to address the issues about the diagnosis and treatment of congenital/perinatal cytomegalovirus infection by presenting a series of infants followed-up in our neonatal intensive care unit. Material and Methods: Medical records of newborn infants with congenital/perinatal cytomegalovirus infection who were admitted to our level ill neonatal intensive care unit between August 2015 and May 2018 were evaluated retrospectively. Only infants who received cytomegalovirus-specific therapy were included. Results: Out of 1039 infants admitted to the neonatal intensive care unit during the study period, 8 (0.8%) were diagnosed and treated for congenital/perinatal cytomegalovirus infections. All of them were preterm infants. Four infants found to be CMV positive during the first 21 days of life were diagnosed as congenital cytomegalovirus infection, while a perinatal and congenital infection differentiation could not be made in the rest of the patients. Anemia (75%), thrombocytopenia (62.5%) and hearing loss (62.5%) were the most common findings in patients with congenital/perinatal infection. None of the infants had chorioretinitis. Two infants (25%) with microcephaly had intracranial calcifications. Sepsis-like findings were present in three very preterm infants (37.5%). Cytomegalovirus-IgM was positive in all 8 infants with infection; however, serum CMV-DNA was positive in seven of them. All infants with moderate to severe symptoms were treated with ganciclovir and/or valganciclovir. Viral load decreased dramatically at the end of the treatment period. Conclusion: Cytomegalovirus infection, either congenital or perinatal, is a greater risk especially for preterm infants who may warrant and benefit from newborn cytomegalovirus screening, early detection, and effective antiviral treatment.
Açıklama
Anahtar Kelimeler
Cytomegalovirus, Congenital Infection, Perinatal Infection, Preterm, Newborn, Preterm Infants, Transmission, Therapy, Disease
Kaynak
Journal Of Pediatric Infection
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
14
Sayı
1
