Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats

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dc.authoridMadendere, Serdar/0000-0001-7020-0276
dc.authoridKaya, Oktay/0000-0001-9639-8022
dc.authoridDeger, Muslim Dogan/0000-0002-5095-7770
dc.authoridTastekin, Ebru/0000-0002-7686-7765
dc.authorwosidMadendere, Serdar/GWM-9709-2022
dc.authorwosidKaya, Oktay/JGL-9169-2023
dc.authorwosidDeger, Muslim Dogan/AAB-2062-2021
dc.contributor.authorSenturk, Irfan Yildirim
dc.contributor.authorDeger, Muslim Dogan
dc.contributor.authorAydin, Muhammed Ali
dc.contributor.authorMadendere, Serdar
dc.contributor.authorKaya, Oktay
dc.contributor.authorTastekin, Ebru
dc.contributor.authorAktoz, Tevfik
dc.date.accessioned2024-06-12T11:16:10Z
dc.date.available2024-06-12T11:16:10Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: This study demonstrated the protective effects of pioglitazone (Pio) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.Materials and Methods: A total of 48 male rats were randomly divided into six experimental groups of eight rats each; Control group, I/R group, Pio 3 mg/kg group, I/R treated with Pio 3 mg/kg group, Pio 6 mg/kg group, and I/R treated with Pio 6 mg/kg group. Testicular torsion was induced by twisting the left testis 720 & DEG;C in a clockwise direction (I/R groups). Both ischemia and reperfusion periods were 4 h. Single-dose 3 mg/kg Pio or 6 mg/kg Pio was administered orally two hours before reperfusion (Pio groups). Left orchiectomy was performed at the end of the protocol.Results: In the I/R within-group analysis for mean seminiferous tubule diameter and epithelial lengths, a statistically significant difference was found only in the Pio 6 group (p=0.005; p=0.005). But Pio treatment failed to improve the levels of malondialdehyde and glutathione. Also, it did not cause any change in the non-I/R groups.Conclusion: Considering the findings of Pio, it may be used in emergencies such as torsion and other chronic diseases.en_US
dc.identifier.doi10.4274/jus.galenos.2022.2022.0047
dc.identifier.endpage172en_US
dc.identifier.issn2148-9580
dc.identifier.issue2en_US
dc.identifier.startpage167en_US
dc.identifier.trdizinid1179722en_US
dc.identifier.urihttps://doi.org/10.4274/jus.galenos.2022.2022.0047
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1179722
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24205
dc.identifier.volume10en_US
dc.identifier.wosWOS:001012104400012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal Of Urological Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTesticular Torsionen_US
dc.subjectIschemiaen_US
dc.subjectReperfusionen_US
dc.subjectDamageen_US
dc.titlePioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Ratsen_US
dc.typeArticleen_US

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