Pioglitazone Eases Testicular Torsion/Detorsion-Induced Ischemia-Reperfusion Injury in Rats
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Publ House
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: This study demonstrated the protective effects of pioglitazone (Pio) on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.Materials and Methods: A total of 48 male rats were randomly divided into six experimental groups of eight rats each; Control group, I/R group, Pio 3 mg/kg group, I/R treated with Pio 3 mg/kg group, Pio 6 mg/kg group, and I/R treated with Pio 6 mg/kg group. Testicular torsion was induced by twisting the left testis 720 & DEG;C in a clockwise direction (I/R groups). Both ischemia and reperfusion periods were 4 h. Single-dose 3 mg/kg Pio or 6 mg/kg Pio was administered orally two hours before reperfusion (Pio groups). Left orchiectomy was performed at the end of the protocol.Results: In the I/R within-group analysis for mean seminiferous tubule diameter and epithelial lengths, a statistically significant difference was found only in the Pio 6 group (p=0.005; p=0.005). But Pio treatment failed to improve the levels of malondialdehyde and glutathione. Also, it did not cause any change in the non-I/R groups.Conclusion: Considering the findings of Pio, it may be used in emergencies such as torsion and other chronic diseases.
Açıklama
Anahtar Kelimeler
Testicular Torsion, Ischemia, Reperfusion, Damage
Kaynak
Journal Of Urological Surgery
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
10
Sayı
2
