Clinical Features and Treatment Strategies of Primary Central Nervous System Lymphoma: a Multicenter Retrospective Study

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dc.contributor.authorDemirci, Koray
dc.contributor.authorPamuk, Gülsüm Emel
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorKılıç, Oğuz
dc.contributor.authorŞıvgın, Serdar
dc.contributor.authorMaden, Muhammet
dc.contributor.authorKuku, İrfan
dc.date.accessioned2021-11-20T10:26:59Z
dc.date.available2021-11-20T10:26:59Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAims: Primary central nervous system lymphoma is a rare, highly malignant disease with poor prognosis. Thecurrent knowledge about the disease is mostly gathered from prospective clinical trials and the optimal treatment modality is still a matter of debate. In this study it is aimed to acquire more information about the clinical features of the disease and the responses to different treatment modalities.Methods: The archives in Trakya University Hospital, İnönü University Turgut Özal Medical Center, PamukkaleUniversity Hospital and Erciyes University Hospital researched retrospectively. Demographic, treatment and survival data were retrieved and their statistical analysis was performed. As descriptive statistics number and percentages, arithmetic mean ± standard deviation, median (maximum-minimum) were used. Survival analysis was performed using Kaplan- Meier method.Results: Median age of patients at diagnosis was 53 and out of 28 patients 15 (53.6 %) of them were male. As the symptoms of the disease 18 (66.7%) patients presented headache, 15 (53.8%) presented focal deficit. As initial treatment 26 (92.9%) patients received chemotherapy, while 19 (67.9%) patients were treated with surgical resection and the median overall survival time was 7 months. Conclusion: Achieving complete remission as response to the initial treatment is associated with an improvedoverall survival. Other survival analysis to compare the impact of all initial treatment methods on overall survival resulted statistically insignificanten_US
dc.identifier.dergipark379015en_US
dc.identifier.endpage132en_US
dc.identifier.issn2148-4724
dc.identifier.issn2548-0030
dc.identifier.issue3en_US
dc.identifier.startpage128en_US
dc.identifier.urihttps://dergipark.org.tr/tr/pub/tmsj/issue/34300/379015
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/404640
dc.identifier.urihttps://hdl.handle.net/20.500.14551/6244
dc.identifier.volume2en_US
dc.language.isoenen_US
dc.publisherTrakya Üniversitesien_US
dc.relation.ispartofTurkish Medical Student Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Başka Kurum Yazarıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-Hodgkin Lymphomaen_US
dc.subjectremissionen_US
dc.subjectchemotherapyen_US
dc.subjectradiotherapyen_US
dc.titleClinical Features and Treatment Strategies of Primary Central Nervous System Lymphoma: a Multicenter Retrospective Studyen_US
dc.typeArticleen_US

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Turkish Medical Student Journal