The determination of hepatotoxic effects in halothane and sevoflurane anaesthesia in rabbits and the role of catechin in prevention of hepatotoxicity

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dc.authorscopusid7003311524
dc.authorscopusid57197111786
dc.authorscopusid6603246084
dc.authorscopusid6603146618
dc.contributor.authorKaramanlio?lu B.
dc.contributor.authorYüksel M.
dc.contributor.authorAktaş R.G.
dc.contributor.authorÇiftçi Ş.
dc.date.accessioned2024-06-12T10:28:19Z
dc.date.available2024-06-12T10:28:19Z
dc.date.issued2001
dc.description.abstractIn experimental study, we aimed to investigate the role of catechin in prevention of hepatotoxicity and to determine the hepatotoxic effects caused by halothane and sevoflurane. In study, 50 male New Zealand rabbits were randomly divided into five groups. Enzyme induction was done to the rabbits by phenobarbital. None of the anaesthetic agents have been applied to Group I (control). In Groups II and III, 1 % halothane, and in Groups IV and V 3 % sevoflurane was used in a mixture of %15/85 O2/N2O for 2 hours. In Group III and V, before the volatile anaesthetics, catechin have been used for 3 weeks by adding (400 mg/kg) into the drinking water of rabbits. In all groups, quantitative hepatobiliary sintigraphy was performed using Tc-99m mebrofenin, and the activity peak uptake time and half-life times in liver were calculated. Histochemical analyses such as, level of malondialdehyde, superoxide dismutase, glutathion peroxidase, catalase and also ultrastructural examinations were done on liver specimens. When compared with the other groups, the peak uptake and half-life times of activity in Group III and especially in Group II were found to be significantly longer (p<0.01, p<0.001); but malondialdehyde levels elevated; superoxide dismutase, glutathione peroxidase and catalase levels were decreased (p<0.05; p<0.01, p<0.001); ultrastructural pathological changes were also observed. These findings were seen less significant in Group III than Group II. In consequence, while halothane caused significant hepatotoxicity, sevoflurane had no such side effect. Catechin pretreatment was found to be useful in preventing of halothane-related hepatotoxicity.en_US
dc.identifier.endpage496en_US
dc.identifier.issn1016-5150
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-0035694629en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage489en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17173
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatechin; Halothane; Hepatotoxicity; Sevofluraneen_US
dc.subjectBridatech; Catalase; Catechin; Glutathione Peroxidase; Halothane; Malonaldehyde; Mebrofenin Tc 99m; Phenobarbital; Sevoflurane; Superoxide Dismutase; Animal Experiment; Animal Model; Animal Tissue; Article; Cell Ultrastructure; Chemoprophylaxis; Controlled Study; Dose Time Effect Relation; Drug Half Life; Drug Uptake; Enzyme Induction; Hepatobiliary Scintiscanning; Histochemistry; Histopathology; Inhalation Anesthesia; Liver Level; Liver Protection; Liver Toxicity; Male; Nonhuman; Rabbit; Toxicity Testingen_US
dc.titleThe determination of hepatotoxic effects in halothane and sevoflurane anaesthesia in rabbits and the role of catechin in prevention of hepatotoxicityen_US
dc.title.alternativeTavşanlarda halotan ve sevofluran anestezisinin hepatotoksik etkilerinin belirlenmesi ve hepatotoksisitenin önlenmesinde kateşinin rolüen_US
dc.typeArticleen_US

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