The determination of hepatotoxic effects in halothane and sevoflurane anaesthesia in rabbits and the role of catechin in prevention of hepatotoxicity
Küçük Resim Yok
Tarih
2001
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Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In experimental study, we aimed to investigate the role of catechin in prevention of hepatotoxicity and to determine the hepatotoxic effects caused by halothane and sevoflurane. In study, 50 male New Zealand rabbits were randomly divided into five groups. Enzyme induction was done to the rabbits by phenobarbital. None of the anaesthetic agents have been applied to Group I (control). In Groups II and III, 1 % halothane, and in Groups IV and V 3 % sevoflurane was used in a mixture of %15/85 O2/N2O for 2 hours. In Group III and V, before the volatile anaesthetics, catechin have been used for 3 weeks by adding (400 mg/kg) into the drinking water of rabbits. In all groups, quantitative hepatobiliary sintigraphy was performed using Tc-99m mebrofenin, and the activity peak uptake time and half-life times in liver were calculated. Histochemical analyses such as, level of malondialdehyde, superoxide dismutase, glutathion peroxidase, catalase and also ultrastructural examinations were done on liver specimens. When compared with the other groups, the peak uptake and half-life times of activity in Group III and especially in Group II were found to be significantly longer (p<0.01, p<0.001); but malondialdehyde levels elevated; superoxide dismutase, glutathione peroxidase and catalase levels were decreased (p<0.05; p<0.01, p<0.001); ultrastructural pathological changes were also observed. These findings were seen less significant in Group III than Group II. In consequence, while halothane caused significant hepatotoxicity, sevoflurane had no such side effect. Catechin pretreatment was found to be useful in preventing of halothane-related hepatotoxicity.
Açıklama
Anahtar Kelimeler
Catechin; Halothane; Hepatotoxicity; Sevoflurane, Bridatech; Catalase; Catechin; Glutathione Peroxidase; Halothane; Malonaldehyde; Mebrofenin Tc 99m; Phenobarbital; Sevoflurane; Superoxide Dismutase; Animal Experiment; Animal Model; Animal Tissue; Article; Cell Ultrastructure; Chemoprophylaxis; Controlled Study; Dose Time Effect Relation; Drug Half Life; Drug Uptake; Enzyme Induction; Hepatobiliary Scintiscanning; Histochemistry; Histopathology; Inhalation Anesthesia; Liver Level; Liver Protection; Liver Toxicity; Male; Nonhuman; Rabbit; Toxicity Testing
Kaynak
Turk Anesteziyoloji ve Reanimasyon
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
29
Sayı
9
