The effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cells

Basit Öğe Kaydı
dc.authoridGedikbasi, Asuman/0000-0001-7121-6077;
dc.authorwosidAlpsoy, Seref/Z-1808-2018
dc.authorwosidGedikbasi, Asuman/AAE-3613-2020
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorAlpsoy, Seref
dc.contributor.authorUygur, Ramazan
dc.contributor.authorAktas, Cevat
dc.contributor.authorTopcu, Birol
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboga, Mustafa
dc.contributor.authorKarakaya, Osman
dc.date.accessioned2024-06-12T10:59:48Z
dc.date.available2024-06-12T10:59:48Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the effects of onion (Allium cepa) extracts (ACE) on doxorubicin (DOX)-induced apoptosis in aortic endothelial cells. The rats in the ACE-pretreated group were given a daily dose of 1ml ACE for 14days. To induce aortic endothelial cell apoptosis, DOX (30mgkg1 body weight) was injected intraperitoneally by a single dose and the rats were sacrificed after 48h. To date, no such studies have been performed on antiapoptotic potential of ACE on DOX-induced apoptosis in aortic endothelial cells. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in aortic endothelial cells of the DOX-treated group with ACE therapy. DOX-treated with ACE groups showed a significant decrease in malondialdehyde levels and increased levels of glutathione in comparison with the DOX-treated group. Data from our study show that prevention of endothelial cell apoptosis by ACE may contribute to the restoration of aortic endothelial dysfunction that is associated with DOX treatment. Copyright (c) 2011 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/jat.1750
dc.identifier.endpage369en_US
dc.identifier.issn0260-437X
dc.identifier.issn1099-1263
dc.identifier.issue5en_US
dc.identifier.pmid21989851en_US
dc.identifier.scopus2-s2.0-84875589104en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage364en_US
dc.identifier.urihttps://doi.org/10.1002/jat.1750
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20583
dc.identifier.volume33en_US
dc.identifier.wosWOS:000316699100004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Applied Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxorubicinen_US
dc.subjectAllium Cepaen_US
dc.subjectAortic Endothelial Cellsen_US
dc.subjectTUNELen_US
dc.subjectAntioxidantsen_US
dc.subjectRaten_US
dc.subjectLipid-Peroxidationen_US
dc.subjectNitric-Oxideen_US
dc.subjectAntioxidanten_US
dc.subjectCardiotoxicityen_US
dc.subjectGlutathioneen_US
dc.subjectDysfunctionen_US
dc.subjectInhibitionen_US
dc.subjectAdriamycinen_US
dc.subjectProtectionen_US
dc.subjectAgentsen_US
dc.titleThe effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cellsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu