The effects of onion (Allium cepa) extract on doxorubicin-induced apoptosis in aortic endothelial cells
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this study was to investigate the effects of onion (Allium cepa) extracts (ACE) on doxorubicin (DOX)-induced apoptosis in aortic endothelial cells. The rats in the ACE-pretreated group were given a daily dose of 1ml ACE for 14days. To induce aortic endothelial cell apoptosis, DOX (30mgkg1 body weight) was injected intraperitoneally by a single dose and the rats were sacrificed after 48h. To date, no such studies have been performed on antiapoptotic potential of ACE on DOX-induced apoptosis in aortic endothelial cells. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in aortic endothelial cells of the DOX-treated group with ACE therapy. DOX-treated with ACE groups showed a significant decrease in malondialdehyde levels and increased levels of glutathione in comparison with the DOX-treated group. Data from our study show that prevention of endothelial cell apoptosis by ACE may contribute to the restoration of aortic endothelial dysfunction that is associated with DOX treatment. Copyright (c) 2011 John Wiley & Sons, Ltd.
Açıklama
Anahtar Kelimeler
Doxorubicin, Allium Cepa, Aortic Endothelial Cells, TUNEL, Antioxidants, Rat, Lipid-Peroxidation, Nitric-Oxide, Antioxidant, Cardiotoxicity, Glutathione, Dysfunction, Inhibition, Adriamycin, Protection, Agents
Kaynak
Journal Of Applied Toxicology
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
33
Sayı
5
