A comparative study of the effect of icodextrin based peritoneal dialysis and hemodialysis on lipid metabolism
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Date
2013
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info:eu-repo/semantics/openAccess
Abstract
Dyslipidemia is frequent in patients with end stage renal disease. Excessive peritoneal glucose absorption from high glucose-containing peritoneal dialysis solutions may enhance disturbances on the lipid metabolism of patients on peritoneal dialysis. We compared the effect of icodextrin-based peritoneal dialysis therapy with hemodialysis (HD) therapy on lipid metabolism. A total of 157 non-diabetic patients on dialysis at least for 3 months; 78 patients on Icodextrin-based continuous ambulatory peritoneal dialysis (CAPD) (44 M, 34 F) and 79 patients in HD group (47M, 32F) were included into the study. After 12 h of fasting and before the dialysis session, serum urea, creatinin, glucose, Sodium, potasium, and albumin, total cholesterol (TC), triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL)-C, high-density lipoprotein (HDL)-C, apolipoprotein A (Apo A), apolipoprotein B, and lipoprotein a were measured. TG ( P = 0018) and VLDL ( P = 0.022) were lower in CAPD group than HD group, HDL-C ( P < 0.001) and Apo A ( P = 0.001) were higher in CAPD group than in HD group. A total of 24.4% in CAPD group and 11.4% in HD group ( P < 0.034) had normal serum levels of TG, LDL-C, and HDL-C. More patients in CAPD group (47.4%) had high serum Apo A levels than in HD group (21.5%) ( P = 0.001). We suggest that patients receiving icodextrin-based CAPD may have better TG, HDL-C, and Apo A levels than patients on HD.
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Keywords
Continuous Ambulatory Peritoneal Dialysis; Dislipidemia; Hemodialysis; Icodextrin; Lipoprotein Abnormalities, Albumin; Apolipoprotein A; Apolipoprotein B; Cholesterol; Creatinine; Glucose; High Density Lipoprotein Cholesterol; Icodextrin; Low Density Lipoprotein Cholesterol; Potassium; Sodium; Triacylglycerol; Urea; Very Low Density Lipoprotein; Adult; Aged; Albumin Blood Level; Article; Cholesterol Blood Level; Comparative Study; Continuous Ambulatory Peritoneal Dialysis; Controlled Study; Creatinine Blood Level; Dyslipidemia; Female; Glucose Blood Level; Hemodialysis; Hemodialysis Patient; Human; Lipid Metabolism; Lipoprotein Blood Level; Major Clinical Study; Male; Peritoneal Dialysis; Potassium Blood Level; Sodium Blood Level; Triacylglycerol Blood Level; Urea Blood Level
Journal or Series
Indian Journal of Nephrology
WoS Q Value
Scopus Q Value
Q3
Volume
23
Issue
5
