Analgesic effects of lornoxicam after total abdominal hysterectomy

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dc.authorscopusid36341029600
dc.authorscopusid36339863900
dc.authorscopusid7003369853
dc.contributor.authorSapolya O.
dc.contributor.authorKaramanlhoglu B.
dc.contributor.authorMemis D.
dc.date.accessioned2024-06-12T10:26:25Z
dc.date.available2024-06-12T10:26:25Z
dc.date.issued2007
dc.description.abstractThe authors investigated, in a randomized, placebo-controlled, double-blinded study, the efficacy and safety of lornoxicam on pain after abdominal hysterectomy and on tramadol consumption in patients. Fifty patients were randomized to receive either oral placebo or lornoxicam 8 mg one hour before surgery. Anesthesia was induced with propofol and maintained with sevoflurane in 50 percent N2O/O2 with a fresh gas flow of 2 L/min (50 percent N2O in O2) and fentanyl (2 ?g/kg). All patients received patient-controlled analgesia with tramadol with loading dose of 50 mg; incremental dose of 20 mg; lock out interval of 10 minute; and four-hour limit 300 mg. The incremental dose was increased to 30 mg if analgesia was inadequate after one hour. Patients were studied at one, two, four, eight, 12, and 24 hours for visual analogue (VAS) pain scores, heart rate, mean arterial pressure, penferic oxygen saturation, sedation, tramadol consumption, and length of hospitalization. VAS scores at one hour were significantly lower in the lornoxicam group (p < 0.001). The tramadol consumption at one, two, four, eight, and 12 hours was significantly lower in the lornoxicam group when compared with the placebo group (p < 0.001, p = 0.008, p = 0.029, p = 0.034, p = 0.042, respectively). Sedation scores were similar at all the measured times in the groups. Length of hospitalization was significantly shorter in lornoxicam group (4.8 ± 0.4 day) than placebo group (5.2 ± 0.5 day) (p = 0.005). There was difference in the incidence of nausea between the groups (p = 0.047). The number of patients and the doses of antiemetics given during the first 24 hours after surgery in lornoxicam group were less than those in placebo group (p = 0.003, p = 0.034, respectively). In conclusion, a single oral dose of lornoxicam given preoperatively enhanced the analgesic effect of tramadol, decreasing tramadol consumption and side effects, and shortened the length of hospitalization.en_US
dc.identifier.doi10.5055/jom.2007.0053
dc.identifier.endpage159en_US
dc.identifier.issn1551-7489
dc.identifier.issue3en_US
dc.identifier.pmid18027541en_US
dc.identifier.scopus2-s2.0-34547841298en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage155en_US
dc.identifier.urihttps://doi.org/10.5055/jom.2007.0053
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16836
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWeston Medical Publishingen_US
dc.relation.ispartofJournal of Opioid Managementen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnalgesics Opioid; Hysterectomy; Lornoxicam; Postoperative Pain; Tramadolen_US
dc.subjectAntiemetic Agent; Atracurium; Atropine; Fentanyl; Lornoxicam; Midazolam; Nitrous Oxide; Oxygen; Placebo; Propofol; Sevoflurane; Tramadol; Abdominal Hysterectomy; Adult; Analgesia; Anesthesia Induction; Article; Clinical Article; Clinical Trial; Controlled Clinical Trial; Controlled Study; Double Blind Procedure; Drug Dose Increase; Drug Efficacy; Drug Potentiation; Drug Safety; Drug Use; Female; Flushing; Heart Rate; Human; Length Of Stay; Loading Drug Dose; Mean Arterial Pressure; Nausea; Orthostatic Hypotension; Oxygen Saturation; Pain Assessment; Patient Controlled Analgesia; Postoperative Pain; Preoperative Care; Randomized Controlled Trial; Scoring System; Sedation; Side Effect; Single Drug Dose; Visual Analog Scale; Vomitingen_US
dc.titleAnalgesic effects of lornoxicam after total abdominal hysterectomyen_US
dc.typeArticleen_US

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