Analgesic effects of lornoxicam after total abdominal hysterectomy
Küçük Resim Yok
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Weston Medical Publishing
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The authors investigated, in a randomized, placebo-controlled, double-blinded study, the efficacy and safety of lornoxicam on pain after abdominal hysterectomy and on tramadol consumption in patients. Fifty patients were randomized to receive either oral placebo or lornoxicam 8 mg one hour before surgery. Anesthesia was induced with propofol and maintained with sevoflurane in 50 percent N2O/O2 with a fresh gas flow of 2 L/min (50 percent N2O in O2) and fentanyl (2 ?g/kg). All patients received patient-controlled analgesia with tramadol with loading dose of 50 mg; incremental dose of 20 mg; lock out interval of 10 minute; and four-hour limit 300 mg. The incremental dose was increased to 30 mg if analgesia was inadequate after one hour. Patients were studied at one, two, four, eight, 12, and 24 hours for visual analogue (VAS) pain scores, heart rate, mean arterial pressure, penferic oxygen saturation, sedation, tramadol consumption, and length of hospitalization. VAS scores at one hour were significantly lower in the lornoxicam group (p < 0.001). The tramadol consumption at one, two, four, eight, and 12 hours was significantly lower in the lornoxicam group when compared with the placebo group (p < 0.001, p = 0.008, p = 0.029, p = 0.034, p = 0.042, respectively). Sedation scores were similar at all the measured times in the groups. Length of hospitalization was significantly shorter in lornoxicam group (4.8 ± 0.4 day) than placebo group (5.2 ± 0.5 day) (p = 0.005). There was difference in the incidence of nausea between the groups (p = 0.047). The number of patients and the doses of antiemetics given during the first 24 hours after surgery in lornoxicam group were less than those in placebo group (p = 0.003, p = 0.034, respectively). In conclusion, a single oral dose of lornoxicam given preoperatively enhanced the analgesic effect of tramadol, decreasing tramadol consumption and side effects, and shortened the length of hospitalization.
Açıklama
Anahtar Kelimeler
Analgesics Opioid; Hysterectomy; Lornoxicam; Postoperative Pain; Tramadol, Antiemetic Agent; Atracurium; Atropine; Fentanyl; Lornoxicam; Midazolam; Nitrous Oxide; Oxygen; Placebo; Propofol; Sevoflurane; Tramadol; Abdominal Hysterectomy; Adult; Analgesia; Anesthesia Induction; Article; Clinical Article; Clinical Trial; Controlled Clinical Trial; Controlled Study; Double Blind Procedure; Drug Dose Increase; Drug Efficacy; Drug Potentiation; Drug Safety; Drug Use; Female; Flushing; Heart Rate; Human; Length Of Stay; Loading Drug Dose; Mean Arterial Pressure; Nausea; Orthostatic Hypotension; Oxygen Saturation; Pain Assessment; Patient Controlled Analgesia; Postoperative Pain; Preoperative Care; Randomized Controlled Trial; Scoring System; Sedation; Side Effect; Single Drug Dose; Visual Analog Scale; Vomiting
Kaynak
Journal of Opioid Management
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
3
Sayı
3
