Induction of micronuclei and nuclear abnormalities in erythrocytes of mosquito fish (Gambusia affinis) following exposure to the pyrethroid insecticide lambda-cyhalothrin
Küçük Resim Yok
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present study the induction of micronuclei (MN) and nuclear abnormalities (NA) in erythrocytes of mosquitofish (Gambusia affinis) (Baird & Girard 1853) was studied. Fish were exposed to three different concentrations of lambda-cyhalothrin (LCT) (1 x 10(-4) mu g/l, 2 x 10(-4) mu g/l, 4 x 10(-4) mu g/l) for periods of 6, 12, 24, and 48 h. NA (notched, lobed, blebbed nuclei), MN, bi-nucleated cells, and the ratio of polychromatic erythrocytes (PCEs) to normochromatic erythrocytes (NCEs) were evaluated to assess genotoxicity and cytotoxicity. LCT significantly induced MN and NA in erythrocytes of G. affinis. The PCE/NCE ratio was also decreased after 24- and 48-h treatments of 4 x 10(-4) mu g/l LCT. The results show that LCT has genotoxic and cytotoxic potential on G. affinis. (C) 2011 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Gambusia Affinis, Lambda-Cyhalothrin, Micronucleus, Nuclear Abnormalities, Genotoxicity, Rat Bone-Marrow, Acute Toxicity, Rainbow-Trout, Peripheral Erythrocytes, Pimephales-Promelas, Aquatic Organisms, Mill Effluent, Mitomycin-C, In-Situ, Cells
Kaynak
Mutation Research-Genetic Toxicology And Environmental Mutagenesis
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
726
Sayı
2
