Comparison of human amniotic membrane and hyaluronate/ carboxymethylcellulose membrane for prevention of adhesion formation in rats

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dc.authorscopusid55891544100
dc.authorscopusid55935628400
dc.authorscopusid57193697138
dc.authorscopusid6603267445
dc.authorscopusid6603178324
dc.contributor.authorKelekci S.
dc.contributor.authorUygur D.
dc.contributor.authorYilmaz B.
dc.contributor.authorSut N.
dc.contributor.authorYesildaglar N.
dc.date.accessioned2024-06-12T10:24:57Z
dc.date.available2024-06-12T10:24:57Z
dc.date.issued2007
dc.description.abstractObjectives: To investigate the effectiveness of human amniotic membrane (HAM) in the prevention of postoperative adhesion formation and to compare it with the efficacy of hyaluronate/carboxymethylcellulose (HA/CMC) membrane in a rat model. Methods: Following pilot studies and computer-generated randomization, 23 female Wistar albino rats were operated on in the full study. One of the uterine horns with standard lesions was treated with either HAM (n = 13) or HA/CMC (n = 10) and the other uterine horn served as the control. Second look laparotomies were performed 2 weeks after the operations. Main outcome measures were extent, severity, degree, total adhesion scores and histopathologic characteristics of adhesions. Results: Uterine horns treated with HAM had significantly lower total adhesion scores than the controls (5.15 ± 2.67 vs. 7.92 ± 1.50, P < 0.05). Total adhesion scores of uterine horns treated with HA/CMC membrane were significantly lower than those of the controls (4.30 ± 1.95 vs. 7.50 ± 1.84, P < 0.01). There were no significant differences between the HAM and HA/CMC groups regarding any adhesion scores. Conclusions: HAM and HA/CMC membrane are both effective for prevention of adhesion formation in a rat uterine horn model; however, one does not seem to be more effective than the other. © 2007 Springer-Verlag.en_US
dc.identifier.doi10.1007/s00404-007-0376-7
dc.identifier.endpage359en_US
dc.identifier.issn0932-0067
dc.identifier.issue4en_US
dc.identifier.pmid17492299en_US
dc.identifier.scopus2-s2.0-34548552576en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage355en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-007-0376-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16109
dc.identifier.volume276en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesion; Human Amniotic Membrane; Rat Uterine Horn Model; Surgical Barriersen_US
dc.subjectCarboxymethylcellulose; Hyaluronic Acid; Amnion Fluid; Animal Experiment; Animal Tissue; Article; Controlled Study; Female; Histopathology; Laparotomy; Nonhuman; Outcome Assessment; Pilot Study; Postoperative Adhesion; Postoperative Complication; Rat; Scoring System; Statistical Significance; Uterus Horn; Wistar Rat; Adhesions; Amnion; Animals; Biocompatible Materials; Carboxymethylcellulose; Female; Gynecologic Surgical Procedures; Humans; Hyaluronic Acid; Membranes, Artificial; Models, Animal; Postoperative Complications; Rats; Rats, Wistar; Uterusen_US
dc.titleComparison of human amniotic membrane and hyaluronate/ carboxymethylcellulose membrane for prevention of adhesion formation in ratsen_US
dc.typeArticleen_US

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