Comparison of human amniotic membrane and hyaluronate/ carboxymethylcellulose membrane for prevention of adhesion formation in rats
Küçük Resim Yok
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: To investigate the effectiveness of human amniotic membrane (HAM) in the prevention of postoperative adhesion formation and to compare it with the efficacy of hyaluronate/carboxymethylcellulose (HA/CMC) membrane in a rat model. Methods: Following pilot studies and computer-generated randomization, 23 female Wistar albino rats were operated on in the full study. One of the uterine horns with standard lesions was treated with either HAM (n = 13) or HA/CMC (n = 10) and the other uterine horn served as the control. Second look laparotomies were performed 2 weeks after the operations. Main outcome measures were extent, severity, degree, total adhesion scores and histopathologic characteristics of adhesions. Results: Uterine horns treated with HAM had significantly lower total adhesion scores than the controls (5.15 ± 2.67 vs. 7.92 ± 1.50, P < 0.05). Total adhesion scores of uterine horns treated with HA/CMC membrane were significantly lower than those of the controls (4.30 ± 1.95 vs. 7.50 ± 1.84, P < 0.01). There were no significant differences between the HAM and HA/CMC groups regarding any adhesion scores. Conclusions: HAM and HA/CMC membrane are both effective for prevention of adhesion formation in a rat uterine horn model; however, one does not seem to be more effective than the other. © 2007 Springer-Verlag.
Açıklama
Anahtar Kelimeler
Adhesion; Human Amniotic Membrane; Rat Uterine Horn Model; Surgical Barriers, Carboxymethylcellulose; Hyaluronic Acid; Amnion Fluid; Animal Experiment; Animal Tissue; Article; Controlled Study; Female; Histopathology; Laparotomy; Nonhuman; Outcome Assessment; Pilot Study; Postoperative Adhesion; Postoperative Complication; Rat; Scoring System; Statistical Significance; Uterus Horn; Wistar Rat; Adhesions; Amnion; Animals; Biocompatible Materials; Carboxymethylcellulose; Female; Gynecologic Surgical Procedures; Humans; Hyaluronic Acid; Membranes, Artificial; Models, Animal; Postoperative Complications; Rats; Rats, Wistar; Uterus
Kaynak
Archives of Gynecology and Obstetrics
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
276
Sayı
4
