Circulating leptin and osteoprotegerin levels affect insulin resistance in healthy premenopausal obese women

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorUgur-Altun, Betul
dc.contributor.authorAltun, Armagan
dc.date.accessioned2024-06-12T11:09:29Z
dc.date.available2024-06-12T11:09:29Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated the relationship between circulating leptin and osteoprotegerin (OPG) levels and insulin resistance assessed by HOMA-IR in premenopausal obese and normal weight women. Thirty four obese women (age 31 +/- 8 years) (BMI 35 +/- 4 kg/ m(2)) with 19 healthy controls (age 31 +/- 7 years) (BMI < 25 kg/m(2)) (BMI 21 +/- 2 kg/ m(2)) were included in the study. Women were healthy and had no osteoporosis. Circulating leptin levels were significantly higher in obese women (17.11 +/- 2.05 ng/ mL vs. 8.38 +/- 4.71 ng/mL, p < 0.0001) and decreased OPG levels were found (14.7 +/- 7.15 pg/mL vs. 19.17 +/- 6.37 pg/mL, p = 0.03). Leptin showed a positive correlation with BMI (r = 0.851, p < 0.0001), waist-to-hip ratio (r = 0.692, p < 0.0001), fasting insulin (r = 0.441, p < 0.001), HOMA-IR (r = 0.412, p = 0.002), fibrinogen (r = 0.387, p = 0.004), uric acid (r = 0.293, p = 0.033), hematocrit (r = 0.394, p = 0.003), systolic (r = 0.504, p < 0.0001), and diastolic blood pressure (r = 0.363, p = 0.008). OPG showed a negative correlation with insulin (r = -0.341, p = 0.013) and HOMA-IR (r = -0.324, p = 0.018). In obese women group, the regression equation of HOMA-IR was (HOMA-IR = [0.095 x leptin]-[0.051 x OPG] + 1.71). However, there was no relation between leptin and OPG levels. In conclusion, circulating leptin and OPG levels were related to insulin resistance in premenopausal obese women. However, leptin had no interference in OPG in premenopausal women. (c) 2007 IMSS. Published by Elsevier Inc.en_US
dc.identifier.doi10.1016/j.arcmed.2007.04.013
dc.identifier.endpage896en_US
dc.identifier.issn0188-4409
dc.identifier.issn1873-5487
dc.identifier.issue8en_US
dc.identifier.pmid17923273en_US
dc.identifier.scopus2-s2.0-34848825690en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage891en_US
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2007.04.013
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22832
dc.identifier.volume38en_US
dc.identifier.wosWOS:000250489400015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofArchives Of Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectOsteoprotegerinen_US
dc.subjectLeptinen_US
dc.subjectInsulin Resistanceen_US
dc.subjectBone-Mineral Densityen_US
dc.subjectKappa-B Liganden_US
dc.subjectSerum Osteoprotegerinen_US
dc.subjectBody-Compositionen_US
dc.subjectReceptor Activatoren_US
dc.subjectRank Liganden_US
dc.subjectHoma-Iren_US
dc.subjectDe-Novoen_US
dc.subjectMetabolismen_US
dc.subjectMassen_US
dc.titleCirculating leptin and osteoprotegerin levels affect insulin resistance in healthy premenopausal obese womenen_US
dc.typeArticleen_US

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