Circulating leptin and osteoprotegerin levels affect insulin resistance in healthy premenopausal obese women
Küçük Resim Yok
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We investigated the relationship between circulating leptin and osteoprotegerin (OPG) levels and insulin resistance assessed by HOMA-IR in premenopausal obese and normal weight women. Thirty four obese women (age 31 +/- 8 years) (BMI 35 +/- 4 kg/ m(2)) with 19 healthy controls (age 31 +/- 7 years) (BMI < 25 kg/m(2)) (BMI 21 +/- 2 kg/ m(2)) were included in the study. Women were healthy and had no osteoporosis. Circulating leptin levels were significantly higher in obese women (17.11 +/- 2.05 ng/ mL vs. 8.38 +/- 4.71 ng/mL, p < 0.0001) and decreased OPG levels were found (14.7 +/- 7.15 pg/mL vs. 19.17 +/- 6.37 pg/mL, p = 0.03). Leptin showed a positive correlation with BMI (r = 0.851, p < 0.0001), waist-to-hip ratio (r = 0.692, p < 0.0001), fasting insulin (r = 0.441, p < 0.001), HOMA-IR (r = 0.412, p = 0.002), fibrinogen (r = 0.387, p = 0.004), uric acid (r = 0.293, p = 0.033), hematocrit (r = 0.394, p = 0.003), systolic (r = 0.504, p < 0.0001), and diastolic blood pressure (r = 0.363, p = 0.008). OPG showed a negative correlation with insulin (r = -0.341, p = 0.013) and HOMA-IR (r = -0.324, p = 0.018). In obese women group, the regression equation of HOMA-IR was (HOMA-IR = [0.095 x leptin]-[0.051 x OPG] + 1.71). However, there was no relation between leptin and OPG levels. In conclusion, circulating leptin and OPG levels were related to insulin resistance in premenopausal obese women. However, leptin had no interference in OPG in premenopausal women. (c) 2007 IMSS. Published by Elsevier Inc.
Açıklama
Anahtar Kelimeler
Obesity, Osteoprotegerin, Leptin, Insulin Resistance, Bone-Mineral Density, Kappa-B Ligand, Serum Osteoprotegerin, Body-Composition, Receptor Activator, Rank Ligand, Homa-Ir, De-Novo, Metabolism, Mass
Kaynak
Archives Of Medical Research
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
38
Sayı
8
