Relationship between lymphovascular invasion and clinicopathological features of papillary thyroid carcinoma

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dc.authoridCelik, Mehmet/0000-0001-7364-370X
dc.authoridAytürk Salt, Semra/0000-0002-1560-3459
dc.authorwosidCelik, Mehmet/AAA-8773-2021
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidAytürk Salt, Semra/U-4265-2017
dc.contributor.authorSezer, Atakan
dc.contributor.authorCelik, Mehmet
dc.contributor.authorBulbul, Buket Yilmaz
dc.contributor.authorCan, Nuray
dc.contributor.authorTastekin, Ebru
dc.contributor.authorAyturk, Semra
dc.contributor.authorUstun, Funda
dc.date.accessioned2024-06-12T11:12:02Z
dc.date.available2024-06-12T11:12:02Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractLymphovascular invasion (LVI) is an important prognostic factor in various solid tumors, however, data on the association between LVI and thyroid carcinomas are limited. In this study, we evaluated the relationship between LVI and clinicopathological features of papillary thyroid carcinoma (PTC). Six hundred seventy- eight patients diagnosed with PTC between 2012 and 2015 were included into the study. Patients were classified based on the presence or absence of LVI. Gender, age, ultrasonography (US), tumor size and multifocality, BRAFV600E mutation, perineural and capsular invasion, extrathyroid extension (ETE), nodal metastasis, and recurrences were evaluated, and risk analysis was performed for each parameter. The number of patients with LVI [LVI (+)] was 63, while the number of patients without LVI [LVI (-)] was 615. The female/male ratio was 564/114. LVI was present in 18.4% of male patients and in 7.4 % of female patients. In the age group between 17- 25 years LVI was detected in 6/13 patients, and this result was statistically significant compared to other age groups (p = 0.004). Suspicious lymph nodes upon US, perineural or capsular invasion, ETE, tumor size, and nodal metastasis were significantly more frequent in LVI (+) group (p < 0.001). The frequency of BRAFV600E mutation was also significantly higher in LVI (+) group (p < 0.001). Overall, the presence of LVI was associated with gender, tumor size, age, lymph node metastasis, pathological lymph nodes, perineural and capsular invasion, ETE, and BRAFV600E mutation. These results suggest that in PTC patients undergoing thyroidectomy, the presence of LVI should be considered as an indicator of aggressive clinicopathological features and those patients should be followed up carefully for recurrences and metastasis.en_US
dc.identifier.doi10.17305/bjbms.2017.1924
dc.identifier.endpage151en_US
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue2en_US
dc.identifier.pmid28284178en_US
dc.identifier.scopus2-s2.0-85019730101en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage144en_US
dc.identifier.urihttps://doi.org/10.17305/bjbms.2017.1924
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23014
dc.identifier.volume17en_US
dc.identifier.wosWOS:000405628800010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.ispartofBosnian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPapillary Thyroid Carcinomaen_US
dc.subjectClinicopathological Featuresen_US
dc.subjectLymphovascularen_US
dc.subjectPTCen_US
dc.subjectLVIen_US
dc.subjectLymphovascular Invasionen_US
dc.subjectBRAFV600E Mutationen_US
dc.subjectLymph-Node Metastasisen_US
dc.subjectVascular Invasionen_US
dc.subjectPrognostic Importanceen_US
dc.subjectPerineural Invasionen_US
dc.subjectCanceren_US
dc.subjectSurvivalen_US
dc.subjectAssociationen_US
dc.subjectDefinitionen_US
dc.subjectRecurrenceen_US
dc.subjectOutcomesen_US
dc.titleRelationship between lymphovascular invasion and clinicopathological features of papillary thyroid carcinomaen_US
dc.typeArticleen_US

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