Relationship between lymphovascular invasion and clinicopathological features of papillary thyroid carcinoma
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Lymphovascular invasion (LVI) is an important prognostic factor in various solid tumors, however, data on the association between LVI and thyroid carcinomas are limited. In this study, we evaluated the relationship between LVI and clinicopathological features of papillary thyroid carcinoma (PTC). Six hundred seventy- eight patients diagnosed with PTC between 2012 and 2015 were included into the study. Patients were classified based on the presence or absence of LVI. Gender, age, ultrasonography (US), tumor size and multifocality, BRAFV600E mutation, perineural and capsular invasion, extrathyroid extension (ETE), nodal metastasis, and recurrences were evaluated, and risk analysis was performed for each parameter. The number of patients with LVI [LVI (+)] was 63, while the number of patients without LVI [LVI (-)] was 615. The female/male ratio was 564/114. LVI was present in 18.4% of male patients and in 7.4 % of female patients. In the age group between 17- 25 years LVI was detected in 6/13 patients, and this result was statistically significant compared to other age groups (p = 0.004). Suspicious lymph nodes upon US, perineural or capsular invasion, ETE, tumor size, and nodal metastasis were significantly more frequent in LVI (+) group (p < 0.001). The frequency of BRAFV600E mutation was also significantly higher in LVI (+) group (p < 0.001). Overall, the presence of LVI was associated with gender, tumor size, age, lymph node metastasis, pathological lymph nodes, perineural and capsular invasion, ETE, and BRAFV600E mutation. These results suggest that in PTC patients undergoing thyroidectomy, the presence of LVI should be considered as an indicator of aggressive clinicopathological features and those patients should be followed up carefully for recurrences and metastasis.
Açıklama
Anahtar Kelimeler
Papillary Thyroid Carcinoma, Clinicopathological Features, Lymphovascular, PTC, LVI, Lymphovascular Invasion, BRAFV600E Mutation, Lymph-Node Metastasis, Vascular Invasion, Prognostic Importance, Perineural Invasion, Cancer, Survival, Association, Definition, Recurrence, Outcomes
Kaynak
Bosnian Journal Of Basic Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
17
Sayı
2
