The role of histamine H-1 receptors in the thermoregulatory effect of morphine in mice

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorUlugol, A
dc.contributor.authorKaradag, HC
dc.contributor.authorDokmeci, D
dc.contributor.authorBaldik, Y
dc.contributor.authorDokmeci, I
dc.date.accessioned2024-06-12T11:08:43Z
dc.date.available2024-06-12T11:08:43Z
dc.date.issued1996
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMorphine is known to release histamine from mast cells and increase the turnover of neuronal histamine. It is also known that histamine receptors mediate some of the morphine effects. The contribution of histamine H-1 and H-2 receptors to the thermoregulatory effect of morphine in mice was investigated in the present experiments. Morphine produced a hypothermic effect, especially at the dose of 10 mg/kg. Although the histamine H-1 receptor antagonist, dimethindene (0.1 mg/kg, i.p.), attenuated the hypothermic effect of morphine (10 mg/kg), a histamine H-2 receptor antagonist, ranitidine (100 mg/kg, i.p.), had no effect. These results suggest that the hypothermic effect of morphine in mice is mediated, at least partly, through histamine H-1 receptors.en_US
dc.identifier.doi10.1016/0014-2999(96)00260-9
dc.identifier.endpage52en_US
dc.identifier.issn0014-2999
dc.identifier.issue1en_US
dc.identifier.pmid8836631en_US
dc.identifier.scopus2-s2.0-0030579818en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://doi.org/10.1016/0014-2999(96)00260-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22542
dc.identifier.volume308en_US
dc.identifier.wosWOS:A1996UZ23800006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMorphineen_US
dc.subjectHistamineen_US
dc.subjectColonic Temperatureen_US
dc.subjectHistamine Receptor Antagonisten_US
dc.subjectBrain Histamineen_US
dc.subjectMouse-Brainen_US
dc.subjectMast-Cellsen_US
dc.subjectTemperatureen_US
dc.subjectInvolvementen_US
dc.subjectReleaseen_US
dc.subjectSystemen_US
dc.subjectRaten_US
dc.subjectProstaglandinsen_US
dc.subjectResponsesen_US
dc.titleThe role of histamine H-1 receptors in the thermoregulatory effect of morphine in miceen_US
dc.typeArticleen_US

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