The role of histamine H-1 receptors in the thermoregulatory effect of morphine in mice
Küçük Resim Yok
Tarih
1996
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Morphine is known to release histamine from mast cells and increase the turnover of neuronal histamine. It is also known that histamine receptors mediate some of the morphine effects. The contribution of histamine H-1 and H-2 receptors to the thermoregulatory effect of morphine in mice was investigated in the present experiments. Morphine produced a hypothermic effect, especially at the dose of 10 mg/kg. Although the histamine H-1 receptor antagonist, dimethindene (0.1 mg/kg, i.p.), attenuated the hypothermic effect of morphine (10 mg/kg), a histamine H-2 receptor antagonist, ranitidine (100 mg/kg, i.p.), had no effect. These results suggest that the hypothermic effect of morphine in mice is mediated, at least partly, through histamine H-1 receptors.
Açıklama
Anahtar Kelimeler
Morphine, Histamine, Colonic Temperature, Histamine Receptor Antagonist, Brain Histamine, Mouse-Brain, Mast-Cells, Temperature, Involvement, Release, System, Rat, Prostaglandins, Responses
Kaynak
European Journal Of Pharmacology
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
308
Sayı
1
