Evaluation of the Effects of Enamel Matrix Protein Derivatives on Clinical Attachment Gain in Periodontal Defects and on Proliferation and Differentiation of Periodontal Ligament Fibroblasts In Vitro: A Double-blind Study

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dc.authoriddikilitas, ahu/0000-0003-4130-2526
dc.authorwosiddikilitas, ahu/KBA-3180-2024
dc.contributor.authorDikilitas, Ahu
dc.contributor.authorTaspinar, Mehmet
dc.contributor.authorInanc, Bulend
dc.date.accessioned2024-06-12T11:00:23Z
dc.date.available2024-06-12T11:00:23Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: This work assesss the effect of enamel matrix protein derivatives (EMD) on the periodontal ligament (PDL) fibroblasts in vitro, and its possible contribution to guided tissue regeneration (GTR) in the therapy of intrabony defects. Materials and Methods: Forty-one intrabony defects were cured randomly with either EMD or GTR (22) or only with GTR (19). Osteogenic differentiation of PDL fibroblasts was measured usage enzyme-linked immunosorbent method. Results: EMD have been demonstrate to increase the proliferation rate, osteogenic differentiation and mineralization of PDL fibroblasts in vitro. Conclusion: EMD has inductive impacts on PDL fibroblasts proliferation and differentiation in vitro, although it's possible contribution to periodontal attachment gain remains below a statistically significant level of clinical detection when combined with GTR.en_US
dc.description.sponsorshipUniversity of Van Yuzuncu Yil [2014-SBE-DO74]en_US
dc.description.sponsorshipThis study was supported bye the University of Van Yuzuncu Yil (funding no: 2014-SBE-DO74).en_US
dc.identifier.doi10.4274/meandros.galenos.2021.72602
dc.identifier.endpage207en_US
dc.identifier.issn2149-9063
dc.identifier.issue2en_US
dc.identifier.startpage200en_US
dc.identifier.trdizinid534324en_US
dc.identifier.urihttps://doi.org/10.4274/meandros.galenos.2021.72602
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/534324
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20797
dc.identifier.volume23en_US
dc.identifier.wosWOS:000823144900011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofMeandros Medical And Dental Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEnamel Matrix Derivativesen_US
dc.subjectFibroblastsen_US
dc.subjectGuided Tissue Regenerationen_US
dc.subjectPeriodontal Ligamenten_US
dc.subjectContained Intrabony Defectsen_US
dc.subjectGuided Tissue Regenerationen_US
dc.subjectBony Defectsen_US
dc.subjectAccess Flapen_US
dc.subjectOutcomesen_US
dc.subjectCellsen_US
dc.titleEvaluation of the Effects of Enamel Matrix Protein Derivatives on Clinical Attachment Gain in Periodontal Defects and on Proliferation and Differentiation of Periodontal Ligament Fibroblasts In Vitro: A Double-blind Studyen_US
dc.typeArticleen_US

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