Evaluation of the Effects of Enamel Matrix Protein Derivatives on Clinical Attachment Gain in Periodontal Defects and on Proliferation and Differentiation of Periodontal Ligament Fibroblasts In Vitro: A Double-blind Study
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Publ House
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: This work assesss the effect of enamel matrix protein derivatives (EMD) on the periodontal ligament (PDL) fibroblasts in vitro, and its possible contribution to guided tissue regeneration (GTR) in the therapy of intrabony defects. Materials and Methods: Forty-one intrabony defects were cured randomly with either EMD or GTR (22) or only with GTR (19). Osteogenic differentiation of PDL fibroblasts was measured usage enzyme-linked immunosorbent method. Results: EMD have been demonstrate to increase the proliferation rate, osteogenic differentiation and mineralization of PDL fibroblasts in vitro. Conclusion: EMD has inductive impacts on PDL fibroblasts proliferation and differentiation in vitro, although it's possible contribution to periodontal attachment gain remains below a statistically significant level of clinical detection when combined with GTR.
Açıklama
Anahtar Kelimeler
Enamel Matrix Derivatives, Fibroblasts, Guided Tissue Regeneration, Periodontal Ligament, Contained Intrabony Defects, Guided Tissue Regeneration, Bony Defects, Access Flap, Outcomes, Cells
Kaynak
Meandros Medical And Dental Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
23
Sayı
2
