Dexmedetomidine reduces rocuronium dose requirement in sevoflurane anaesthesia

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dc.authorscopusid7003369853
dc.authorscopusid7004533485
dc.authorscopusid7003311524
dc.authorscopusid7005822791
dc.authorscopusid6701467427
dc.contributor.authorMemiş D.
dc.contributor.authorTuran A.
dc.contributor.authorKaramanlio?lu B.
dc.contributor.authorŞeker S.
dc.contributor.authorPamukçu Z.
dc.date.accessioned2024-06-12T10:24:59Z
dc.date.available2024-06-12T10:24:59Z
dc.date.issued2008
dc.description.abstractBackground: We evaluated the effect of dexmedetomidine infusion on rocuronium dose requirement, haemodynamic parameters, and the recovery of neuromuscular blockade during sevoflurane anaesthesia in patients. Material: This randomized study was conducted on 40 ASA I-II patients. Neuromuscular block was measured by stimulation of the ulnar nerve and acceleromyograph of adductor pollicis muscle. After tracheal intubation; patients received either 1.0 ?/kg over 10 min followed by a maintenance 0.2 ?g/kg/h of dexmedetomidine (Group D)(n=20) or the same volume saline infusion (Group C)(n=20). After this, 0.6 mg/kg rocuronium was given to all patients. The incremental doses of rocuronium (0.15 mg/kg) were repeated to maintain muscle relaxation at the level of with T1 just positive or maximum up to 10% of its control. The variables recorded were times to recovery of T1 to 25%, 75%, and 90% of control and total dose of rocuronium used during surgery. Heart rate, and mean arterial pressure were recorded. The extubation criteria were adequate recovery of neuromuscular function as judged by TOF ratio >0.95. Results: There were significant decreases in heart rate, and mean arterial pressure in group D 15 min after intubation. The times to T1 of 25% was also significantly longer in the dexmedetomidine group (54±13 vs 35±6.7 min, respectively, p=0.001). There were no significant variables in recovery time between groups (T1 25-75%, 14.5±6.8 vs 12±5 min, respectively, p=0.193). The time required to a 90%T1 recovery was significantly longer in the dexmedetomidine group (86±29.2 vs 58±15.3 min, respectively, p=0.005). The total dose requirement of rocuronium was significantly lower in the dexmedetomidine group (61.5±4.65 vs 74±5.21 mg respectively, p=0.001). Conclusion: We concluded that dexmedetomidine infusion reduced rocuronium dose requirement, decreased hemodynamic parameters during sevoflurane anaesthesia. © 2008 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.cacc.2007.07.001
dc.identifier.endpage174en_US
dc.identifier.issn0953-7112
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-48149086021en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://doi.org/10.1016/j.cacc.2007.07.001
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16140
dc.identifier.volume19en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofCurrent Anaesthesia and Critical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDexmedetomidine; Hemodynamic Parameters; Recovery Of Neuromuscular Blockade; Rocuronium Dose Requirement; Sevoflurane Anaesthesiaen_US
dc.subjectAlfentanil; Dexmedetomidine; Ephedrine; Midazolam; Nitrous Oxide; Propofol; Rocuronium; Sevoflurane; Sodium Chloride; Suxamethonium; Adult; Anesthetic Recovery; Article; Clinical Trial; Controlled Clinical Trial; Controlled Study; Drug Dose Titration; Drug Infusion; Endotracheal Intubation; Extubation; Female; Heart Rate; Hemodynamic Parameters; Human; Inhalation Anesthesia; Maintenance Drug Dose; Male; Mean Arterial Pressure; Muscle Relaxation; Myography; Nerve Stimulation; Neuromuscular Blocking; Neuromuscular Function; Priority Journal; Randomized Controlled Trial; Ulnar Nerveen_US
dc.titleDexmedetomidine reduces rocuronium dose requirement in sevoflurane anaesthesiaen_US
dc.typeArticleen_US

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