Dexmedetomidine reduces rocuronium dose requirement in sevoflurane anaesthesia
Küçük Resim Yok
Tarih
2008
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: We evaluated the effect of dexmedetomidine infusion on rocuronium dose requirement, haemodynamic parameters, and the recovery of neuromuscular blockade during sevoflurane anaesthesia in patients. Material: This randomized study was conducted on 40 ASA I-II patients. Neuromuscular block was measured by stimulation of the ulnar nerve and acceleromyograph of adductor pollicis muscle. After tracheal intubation; patients received either 1.0 ?/kg over 10 min followed by a maintenance 0.2 ?g/kg/h of dexmedetomidine (Group D)(n=20) or the same volume saline infusion (Group C)(n=20). After this, 0.6 mg/kg rocuronium was given to all patients. The incremental doses of rocuronium (0.15 mg/kg) were repeated to maintain muscle relaxation at the level of with T1 just positive or maximum up to 10% of its control. The variables recorded were times to recovery of T1 to 25%, 75%, and 90% of control and total dose of rocuronium used during surgery. Heart rate, and mean arterial pressure were recorded. The extubation criteria were adequate recovery of neuromuscular function as judged by TOF ratio >0.95. Results: There were significant decreases in heart rate, and mean arterial pressure in group D 15 min after intubation. The times to T1 of 25% was also significantly longer in the dexmedetomidine group (54±13 vs 35±6.7 min, respectively, p=0.001). There were no significant variables in recovery time between groups (T1 25-75%, 14.5±6.8 vs 12±5 min, respectively, p=0.193). The time required to a 90%T1 recovery was significantly longer in the dexmedetomidine group (86±29.2 vs 58±15.3 min, respectively, p=0.005). The total dose requirement of rocuronium was significantly lower in the dexmedetomidine group (61.5±4.65 vs 74±5.21 mg respectively, p=0.001). Conclusion: We concluded that dexmedetomidine infusion reduced rocuronium dose requirement, decreased hemodynamic parameters during sevoflurane anaesthesia. © 2008 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Dexmedetomidine; Hemodynamic Parameters; Recovery Of Neuromuscular Blockade; Rocuronium Dose Requirement; Sevoflurane Anaesthesia, Alfentanil; Dexmedetomidine; Ephedrine; Midazolam; Nitrous Oxide; Propofol; Rocuronium; Sevoflurane; Sodium Chloride; Suxamethonium; Adult; Anesthetic Recovery; Article; Clinical Trial; Controlled Clinical Trial; Controlled Study; Drug Dose Titration; Drug Infusion; Endotracheal Intubation; Extubation; Female; Heart Rate; Hemodynamic Parameters; Human; Inhalation Anesthesia; Maintenance Drug Dose; Male; Mean Arterial Pressure; Muscle Relaxation; Myography; Nerve Stimulation; Neuromuscular Blocking; Neuromuscular Function; Priority Journal; Randomized Controlled Trial; Ulnar Nerve
Kaynak
Current Anaesthesia and Critical Care
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
19
Sayı
3
